%0 Journal Article %1 Woert1975 %A Woert, M. H. Van %A Sethy, V. H. %D 1975 %J Neurology %K 5-Hydroxytryptophan; Adolescent; Adult; Anoxia; Carbidopa; Cerebral Palsy; Dopa Decarb; Drug Therapy, Combination; Female; Homovanillic Acid; Humans; Hydrazines; Hydroxyindoleacetic Male; Methysergide; Middle Aged; Myoclonus; Probenecid; Serotonin; oxylase %N 2 %P 135--140 %T Therapy of intention myoclonus with L-5-hydroxytryptophan and a peripheral decarboxylase inhibitor, MK 486. %V 25 %X Three patients with postanoxic intention myoclonus, two patients with intention tremor, and one patient with cerebral palsy were administered L-5-hydroxytryptophan (L-5HTP), the precursor of serotonin, in combination with MK 486, a peripheral amino acid decarboxylase inhibitor. L-5HTP combined with MK 486 were potent long-term therapeutic agents for postanoxic intention myoclonus, but had no effect on intention tremor or cerebral palsy. These drugs were well-tolerated by the patients, and more effective than any other known therapy for intention myoclonus. Cerebrospinal fluid concentration of 5-hydroxyindoleacetic acid, the main catabolite of serotonin, appeared low in two patients with intention myoclonus and increased markedly during drug therapy. Postanoxic intention myoclonus may be causally related to a deficiency of brain serotonin.

@article{Woert1975, abstract = {Three patients with postanoxic intention myoclonus, two patients with intention tremor, and one patient with cerebral palsy were administered L-5-hydroxytryptophan (L-5HTP), the precursor of serotonin, in combination with MK 486, a peripheral amino acid decarboxylase inhibitor. L-5HTP combined with MK 486 were potent long-term therapeutic agents for postanoxic intention myoclonus, but had no effect on intention tremor or cerebral palsy. These drugs were well-tolerated by the patients, and more effective than any other known therapy for intention myoclonus. Cerebrospinal fluid concentration of 5-hydroxyindoleacetic acid, the main catabolite of serotonin, appeared low in two patients with intention myoclonus and increased markedly during drug therapy. Postanoxic intention myoclonus may be causally related to a deficiency of brain serotonin.}, added-at = {2014-07-19T21:56:20.000+0200}, author = {Woert, M. H. Van and Sethy, V. H.}, biburl = {https://www.bibsonomy.org/bibtex/282296afea2b1f72978d3fe25dce57d61/ar0berts}, groups = {public}, interhash = {f56057904a204c33eb68939321256333}, intrahash = {82296afea2b1f72978d3fe25dce57d61}, journal = {Neurology}, keywords = {5-Hydroxytryptophan; Adolescent; Adult; Anoxia; Carbidopa; Cerebral Palsy; Dopa Decarb; Drug Therapy, Combination; Female; Homovanillic Acid; Humans; Hydrazines; Hydroxyindoleacetic Male; Methysergide; Middle Aged; Myoclonus; Probenecid; Serotonin; oxylase}, month = Feb, number = 2, pages = {135--140}, pmid = {1078720}, timestamp = {2014-07-19T21:56:20.000+0200}, title = {Therapy of intention myoclonus with L-5-hydroxytryptophan and a peripheral decarboxylase inhibitor, MK 486.}, username = {ar0berts}, volume = 25, year = 1975 }