%0 Journal Article %1 Wood.1991 %A Wood, W. G. %D 1991 %J Scand.J.Clin.Lab Invest Suppl %K & Antibodies Buffers Control Hormone Humans Immunoassay Parathyroid Quality Reference Standards Thyrotropin blood data methods numerical standards statistics %P 105-112 %T "Matrix effects" in immunoassays %U PM:1947738 %V 205 %X This article deals with "matrix effects" in immunoassay systems. As each component has its own matrix (buffer, antibody, separation agents), the term matrix effect--usually only referring to the matrix of the sample--has been replaced by the term interference effect. The possible sites of interference have been dealt with in turn, taking each component/step of an immunoassay separately. Results of assay improvement due to the removal of "matrix effects" are given using the PTH-assay as example. The change in results due to tampering with the serum matrix is given using the determination of free thyroxine in commercial quality control sera

@article{Wood.1991, abstract = {This article deals with "matrix effects" in immunoassay systems. As each component has its own matrix (buffer, antibody, separation agents), the term matrix effect--usually only referring to the matrix of the sample--has been replaced by the term interference effect. The possible sites of interference have been dealt with in turn, taking each component/step of an immunoassay separately. Results of assay improvement due to the removal of "matrix effects" are given using the PTH-assay as example. The change in results due to tampering with the serum matrix is given using the determination of free thyroxine in commercial quality control sera}, added-at = {2010-02-05T11:28:39.000+0100}, author = {Wood, W. G.}, biburl = {https://www.bibsonomy.org/bibtex/2fc1f64bf609f025e2be600da22cbf972/kanefendt}, interhash = {f741cfe56e6f9cab240fc6e109627b48}, intrahash = {fc1f64bf609f025e2be600da22cbf972}, journal = {Scand.J.Clin.Lab Invest Suppl}, keywords = {& Antibodies Buffers Control Hormone Humans Immunoassay Parathyroid Quality Reference Standards Thyrotropin blood data methods numerical standards statistics}, pages = {105-112}, timestamp = {2010-02-05T11:28:45.000+0100}, title = {"Matrix effects" in immunoassays}, url = {PM:1947738}, volume = 205, year = 1991 }