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Toward a generalized computational workflow for exploiting transient pockets as new targets for small molecule stabilizers: Application to the homogentisate 1, 2-dioxygenase mutants at the base of rare disease Alkaptonuria.

, , , , , , and . Comput. Biol. Chem., (2017)

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ProCoCoA: A quantitative approach for analyzing protein core composition., , , , , , , , and . Comput. Biol. Chem., (2013)Toward a generalized computational workflow for exploiting transient pockets as new targets for small molecule stabilizers: Application to the homogentisate 1, 2-dioxygenase mutants at the base of rare disease Alkaptonuria., , , , , , and . Comput. Biol. Chem., (2017)Transient pockets as mediators of gas molecules routes inside proteins: The case study of dioxygen pathway in homogentisate 1, 2-dioxygenase and its implication in Alkaptonuria development., , , , and . Comput. Biol. Chem., (2020)Bioinformatics Approaches to Predict Mutation Effects in the Binding Site of the Proangiogenic Molecule CD93., , , , , , , , , and 3 other author(s). Frontiers Bioinform., (2022)Structural bioinformatics survey on disease-inducing missense mutations., , , , and . J. Bioinform. Comput. Biol., 19 (3): 2150008:1-2150008:15 (2021)Machine learning application for patient stratification and phenotype/genotype investigation in a rare disease., , , , , , and . Briefings Bioinform., (2021)Three-dimensional computation of atom depth in complex molecular structures., , , , , , , and . Bioinform., 21 (12): 2856-2860 (2005)A new integrated and interactive tool applicable to inborn errors of metabolism: Application to alkaptonuria., , , , , , , , , and 6 other author(s). Comput. Biol. Medicine, (2018)ApreciseKUre: an approach of Precision Medicine in a Rare Disease., , , , and . BMC Medical Informatics Decis. Mak., 17 (1): 42:1-42:5 (2017)AKUImg: A database of cartilage images of Alkaptonuria patients., , , , , , , , , and . Comput. Biol. Medicine, (2020)