In the Injury Theory, it's damage to the arterial endothelium, followed by platelet activation, then smooth muscle cell migration to injury, then macrophages, with resulting "foam cells." Engorged foam cells burst, starting the injury cycle all over again
The Kuhn Laboratory at TSRI research interest: Making Cancer a Managed Disease...by understanding the clinical significance, molecular mechanisms, and phenotype of circulating tumor cells(CTCs) and their importance in metastasis. Research Topics: Circulating Tumor Cells for Cancer Diagnosis and Prognosis; JCIMPT: JCSG Center for Innovative Membrane Protein Technologies; C-ME: Collaborative Molecular Modelling Environment.