Access to academic research and publications for all those without university library accounts. Full text articles from a fairly useful selection of journals. Not as good as doing research in the biomedical library at UCLA or Dartmouth, but...it allows
The time has come for libraries, too, to negotiate for rights to index full text
By Jonathan Rochkind -- Library Journal, 2/15/2007
The ability to search and receive results in more than one database through a single interface—or metasearch—is something many of our users want. Google Scholar—the search engine of specifically scholarly content—and library metasearch products like Ex Libris's MetaLib, Serials Solution's Central Search, WebFeat, and products based on MuseGlobal used by both academic and public libraries—are all a means of providing this functionality. At the university where I work, without very much local advertising, Google Scholar has become the largest single source of links to our link resolver product, illustrating how hungry users are for metasearch.
Primärquellen zur US-Amerikanischen Geschichte von 1859 bis 1877. Ca. 5000 Bände sind mit OCR digitalisiert. MOA ist seit 1995 ein Kooperationsprojekt zwischen der Cornell University und der University of Michigan. Die Hauptauswahl der Sekundärliteratur umfasst die Erscheinungsjahre 1840 bis 1900.
Glioblastoma (GBM, WHO grade IV astrocytoma) is among the most common adult brain tumors and one that is invariably fatal. GBM is classified as either primary (de novo) or secondary in origin. Secondary GBMs are derived from previously lower grade (WHO grades II or III) gliomas. While secondary GBMs present with similar clinical characteristics as their primary counterparts, the molecular pathways involved in their pathogenesis distinguish the two and have functional consequences for their behavior. Although a large number of histologic markers are routinely utilized to distinguish primary from secondary GBM, advances in genomic and bioinformatics techniques have drastically improved classification of high-grade gliomas and our understanding of the molecular pathways that influence tumor behavior and response to treatment. The significant influence of molecular identity on tumor behavior has been recognized by the most recent WHO classification of CNS tumors, wherein specific molecular markers have been integrated as part of tumor subtype identification process, as a supplement to traditional histological analysis. Indeed, the change heralds a new era for neuro-oncology, one that is moving toward targeted therapeutics as part of the standard of care. Thus, a comprehensive grasp of this diverse landscape is necessary. In this chapter, we provide an overview of our latest understanding of the molecular diversity of GBM, specifically as it pertains to primary and secondary GBMs, and how it influences prognostication and therapeutic decision-making.