Experimental as well as clinical data do not support the hypothesis that atorvastatin or any other statin affects the antithrombotic potency of clopidogrel.
Statins have pleiotropic effects: anti-inflammatory, immunomodulatory, antithrombotic, and vascular activity, & may improve left ventricular myocardial function & left ventricular diastolic function by increasing vascular elasticity.
Coronary collateral circulation is associated with preserved myocardial contractility; preexisting collaterals may be more important than neoangiogenesis for angina & MI patients.
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J Angermann, Christiane E Jahns, Roland Research Support, Non-U.S.
Gov't United States American heart journal Am Heart J. 2006 Oct;152(4):697-704..
J. Schmitt, H. Schunkert, D. Birnbaum, and H. Aebert. Eur J Cardiothorac Surg, 22 (3):
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