We apply a simulational proxy of the -value analysis and perform extensive mutagenesis experiments to identify the nucleating residues in the folding “reactions” of two small lattice G polymers with different native geometries. Our findings show that for the more complex native fold (i.e., the one that is rich in nonlocal, long-range bonds), mutation of the residues that form the folding nucleus leads to a considerably larger increase in the folding time than the corresponding mutati...
ProPhylER shows your protein like you have never seen it before: Through the lens of Evolutionary Constraint, inferred from comparative analyses of closely related sequences.
Innovative. Technically superior. Creative. Reliable. These are words researchers use to describe Pierce, a pioneer and leader in many research disciplines including protein chemistry, sample handling, immunology and chromatography.
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Mitogen-activated protein kinase p38 is a serin/threonine kinase originally isolated from lipopolysaccharide stimulated monocytes. There are 4 isoforms; p38-a activation has been most widely studied for inflammation...
C. Baker, and R. Witte. The 3rd Canadian Working Conference on Computational Biology (CCCB'04), Markham, Ontario, Canada, (October 2004)Co-located with IBM CASCON..
L. Mirny, M. Slutsky, and L. Wunderlich. Abstract Book of the XXIII IUPAP International Conference on Statistical Physics, Genova, Italy, (9-13 July 2007)
K. Joo, J. Lee, I. Kim, S. Lee, and J. Lee. Abstract Book of the XXIII IUPAP International Conference on Statistical Physics, Genova, Italy, (9-13 July 2007)