The first British baby genetically-selected to be free of a breast cancer gene has been born. She grew from an embryo screened to ensure it did not contain the faulty BRCA 1 gene, which passes the risk of breast cancer down generations.
FERTILITY regulators have triggered a new row over designer babies by allowing doctors to destroy embryos affected by more than 100 genetic conditions, including many illnesses that are not life-threatening. The genetic “defects” that can now be routinely screened out include conditions carried by a number of leading figures, such as Pete Sampras, the tennis champion, and Sergei Rachmaninoff, the Russian concert pianist and composer. In some cases it will mean the elimination of an embryo that has been identified as carrying genetic material inherited from a stricken grandparent, but which may not necessarily develop the same illness. The Human Fertilisation and Embryology Authority (HFEA), has published a list of 116 inherited conditions that fertility clinics can screen out without requiring special permission.
The article in the Sunday Times last week ‘Embryos destroyed for minor disorders’ was inaccurate and misleading and could cause confusion and distress for those families undergoing or considering IVF treatment with pre-implantation genetic diagnosis (PGD). PGD is licensed only for serious medical conditions which severely threaten the future health and wellbeing of children. It is not a ‘routine’ procedure. In 2007, out of nearly 37,000 patients who received fertility treatment, 169 had PGD, fewer than one in 200. Embryos are tested when they are just three days old and made up of about eight cells. They are not at the developed stage of the foetus as shown in the photograph.Finally, to suggest that embryos are destroyed for ‘minor conditions’ which would require ‘unpleasant treatment’ is not only misleading, it is disrespectful both to those living with the condition, and those seeking to avoid passing on these serious conditions to their children.
Newspaper stories claiming that fertility regulators in the UK have allowed embryos to be destroyed for 'minor disorders' are unrelated to decisions taken at a recent regulatory meeting. Stories last week said the Human Fertilisation and Embryology Authority (HFEA) had allowed doctors to routinely screen out more than 100 genetic disorders using PGD (preimplantation genetic diagnosis). But, according to HFEA sources, the list of genetic disorders approved for PGD has been on the website for at least three years.
BERLIN — Embryos created during in vitro fertilization can be screened for genetic defects before being implanted in the womb, a German high court said in a landmark ruling Tuesday. The Federal Supreme Court in Leipzig ruled in support of a Berlin gynecologist who had carried out screening on embryos for three different couples and implanted only those that were healthy. The embryos with hereditary genetic defects were left to die off. The high court's ruling upheld a decision by a Berlin state court that the doctor's action did not violate German laws for the protection of embryos. The 47-year-old doctor, who was not identified by the court, brought the case to court himself in 2006 to clarify the legal situation. He was first acquitted by a regional court in Berlin, but the city's state prosecutor appealed.
A decision last week by Germany’s Federal Supreme Court to acquit a gynaecologist of illegal abortion after he chose to carry out genetic diagnosis on several human embryos and discarded those with genetic defects has stirred a debate about the possible need for a new law tightening the rules on preimplantation genetic diagnosis. The landmark ruling said that embryos created from in vitro fertilisation (IVF) can be screened for genetic defects before being implanted in the womb. The 47 year old doctor, who was not identified, brought the case to court himself in 2006 to clarify the legal situation. He had already been acquitted in May 2009 by a regional court in Berlin, but the prosecutor had appealed the decision.
The German chancellor, Angela Merkel, announced her objection to preimplantation genetic diagnosis at a recent party conference. However, she has agreed to a free parliamentary vote on whether to allow pre-screening of fertilised embryos in Germany. Meanwhile her coalition partner has replied that his party would not tolerate a complete ban. Christian Lindner, general secretary of the liberal Free Democratic Party, expressed his “regret that this chancellor, as a scientist, hasn’t given greater recognition to the method.” Officially Germany, in contrast to other European countries, has forbidden preimplantation genetic diagnosis since 1990, under the Embryo Protection Law, but some legal uncertainty remained. In July 2010 the Federal Supreme Court in Leipzig had ruled in support of a Berlin gynaecologist who had carried out screening on embryos for three different couples and implanted only those that were healthy.