Dopamine transmission is involved in reward processing and motor control, and its impairment plays a central role in numerous neurological disorders. Despite its strong pathophysiological relevance, the molecular and structural organization of the dopaminergic synapse remains to be established. Here, we used targeted labelling and fluorescence activated sorting to purify striatal dopaminergic synaptosomes. We provide the proteome of dopaminergic synapses with 57 proteins specifically enriched. Beyond canonical markers of dopamine neurotransmission such as dopamine biosynthetic enzymes and cognate receptors, we validated 6 proteins not previously described as enriched. Moreover, our data reveal the adhesion of dopaminergic synapses to glutamatergic, GABAergic or cholinergic synapses in structures we named “dopamine hub synapses”. At glutamatergic synapses, pre- and postsynaptic markers are significantly increased upon association with dopamine synapses. Dopamine hub synapses may thus support local dopaminergic signalling, complementing volume transmission thought to be the major mechanism by which monoamines modulate network activity. The neurotransmitter dopamine is an important regulator of brain function. Here the authors describe “dopamine hub synapses”, where dopamine transmission may act in synergy with other neurotransmitters.
S. Nešić, D. Gašević, und M. Jazayeri. 7th IEEE International Conference on Advanced Learning Technologies, Niiagata, Japan, IEEE Computer Society, (2007)To appear.
E. Ong, O. Grebner, und U. Riss. 4th Conference on Professional Knowledge Management - Experiences and Visions -, March 28. - 30. 2007, Potsdam, Germany, GITO Verlag Berlin, (März 2007)
N. Krause, und Y. Singer. ICML '04: Proceedings of the twenty-first international conference on Machine learning, Seite 63. New York, NY, USA, ACM Press, (2004)
R. Kondor, und J. Lafferty. ICML '02: Proceedings of the Nineteenth International Conference on Machine Learning, Seite 315--322. San Francisco, CA, USA, Morgan Kaufmann Publishers Inc., (2002)
Y. Jin, Y. Matsuo, und M. Ishizuka. Proceedings of the European Semantic Web Conference, ESWC2007, Volume 4519 von Lecture Notes in Computer Science, Springer-Verlag, (Juli 2007)
R. Witte, Y. Zhang, und J. Rilling. Proceedings of the European Semantic Web Conference, ESWC2007, Volume 4519 von Lecture Notes in Computer Science, Springer-Verlag, (Juli 2007)
C. Brooks, und N. Montanez. WWW '06: Proceedings of the 15th international conference on World Wide Web, Seite 625-632. New York, NY, USA, ACM Press, (2006)
A. Schenker, H. Bunke, M. Last, und A. Kandel. Document Analysis Systems, Volume 3163 von Lecture Notes in Computer Science, Seite 401-412. Springer, (2004)
C. Iglesias, M. Garrijo, und J. Gonzalez. Proceedings of the 5th International Workshop on Intelligent Agents V : Agent Theories, Architectures, and Languages (ATAL-98), 1555, Seite 317--330. Springer-Verlag: Heidelberg, Germany, (1999)
X. Wu, L. Zhang, und Y. Yu. WWW '06: Proceedings of the 15th international conference on World Wide Web, Seite 417--426. New York, NY, USA, ACM Press, (2006)
R. Agrawal, T. Imieli&\#324;ski, und A. Swami. SIGMOD '93: Proceedings of the 1993 ACM SIGMOD international conference on Management of data, Seite 207--216. New York, NY, USA, ACM Press, (1993)
L. Cysneiros, E. Yu, und J. Leite. Workshop on Requirements Engineering for Adaptable Architectures at the International Requirements Engineering Conference (RE'03), Seite 13--20. Monterey Bay, California, (8--12 September 2003)
M. Milewski, und G. Roberts. Proceedings of the 1st Workshop on Models and Aspects - Handling Crosscutting Concerns in MDSD, in conjunction with the 19th European Conference on Object-Oriented Programming, (2005)
P. Desikan, N. Pathak, J. Srivastava, und V. Kumar. ICWE '06: Proceedings of the 6th international conference on Web engineering, Seite 233--240. New York, NY, USA, ACM Press, (Juli 2006)