Very low calorie diets that have been shown to put Type 2 Diabetes in remission in those recently diagnosed with the condition will be trialled as part of the NHS long term plan, which will increase the focus on prevention as well as treatment.
Little is known about temporal trajectories of social support in adults with type 2 diabetes (T2D) and how they are associated with diabetes‐related outcomes. This study identified and explored different trajectories of social support in a community sample of adults with T2D, as well as the extent to which different trajectories were prospectively associated with depressive symptoms and functional disability.. To read the full article, log in using your MPFT NHS OpenAthens details.
Open access. People with type 1 diabetes who attend structured education training in self-management using flexible intensive therapy achieve improved blood glucose control and experience fewer episodes of severe hypoglycaemia. However, many struggle to sustain these improvements over time. To inform the design of more effective follow-up support we undertook a review of qualitative studies which have identified factors that influence and inform participants’ self-management behaviours after attending structured education and their need for support to sustain improvements in glycaemic control.
According to new analysis by Diabetes UK, over 6,500 children and young adults have been reported to have Type 2 diabetes in England and Wales.
The latest figures for 2016-17 show the number of under 25s treated in GP practices for the condition has reached 6,836.
A 5-year-old boy with known type 1 diabetes mellitus (T1DM), treated with insulin, presents to the paediatric diabetes outpatient department for his routine clinic review. The family have started the boy on a ketogenic diet (<50 g of carbohydrates daily with target blood ketones of 2–3 mmol/L) to improve his diabetes control and for additional perceived health benefits. On the ketogenic diet, the patient’s insulin needs decreased, his HbA1c is good (41mmol/L/5.2%) and his height and weight are increasing along the 75th centile for his age. He has normal screening bloods (including lipids) and a normal ECG.
The paediatric diabetes multidisciplinary team traditionally recommend a low-fat, high-carbohydrate diet for children with T1DM. The team have no experience of using a ketogenic or low-carbohydrate diet for the management of T1DM in children treated with insulin. You wonder if there is evidence to support the ketogenic diet in children with T1DM and if there are potential risks associated with the low-carbohydrate diet.. To read the full article, log in using your NHS OpenAthens details.
Pregnant women with gestational diabetes in Shropshire will soon be able to manage their condition remotely by using a smartphone app.
The app will be used by The Shrewsbury and Telford Hospital NHS Trust (SaTH) from December and means that women will be able to better manage their condition, and potentially reduce the number of visits they need to make to hospital.
Following an article on the principles of wound debridement in the previous Tissue Viability Supplement (Lumbers, 2018), this article describes some of the debridement strategies to consider in the care of diabetic foot ulcers (DFUs).
Foot-ulcer-related problems account for 20% of hospital admissions due to their effects on pain, mobility and systemic infection (Papanas et al, 2013). This article will cover broad concepts with the aim of improving understanding of the prevalence and outcomes of diabetic foot disease, why those with diabetes develop foot wounds, why such wounds can be difficult to heal and the evidence for various debridement techniques to support DFU healing. To read the full article, log in using your MPFT NHS OpenAthens details.
To coincide with World Diabetes Day, Simon Stevens, Chief Executive of NHS England, is announcing action to end the current variation patients in some parts of the country are facing to access Freestyle Libre.
The wearable sensor does away with the need for inconvenient and sometimes painful finger prick blood tests by relaying glucose levels to a smart phone or e-reader.
Over a million people with diabetes were admitted to hospital in England in 2017. 92% of them were not admitted because of their diabetes. A hospital stay for a person with diabetes can be a frightening experience and it is easy to understand why. In 2017, an estimated 9,600 people required rescue treatment following a severe hypoglycaemic attack. 2,200 people suffered from Diabetic Ketoacidosis (DKA) due to under treatment with insulin . We can and must do better for people with diabetes in hospital.
This report shows prescribing trends for medicines prescribed in primary care in England for the treatment of diabetes.
This is the latest in a series of annual reports published by NHS Digital on Prescribing for Diabetes in England, within primary care.
In this cohort study of 2204 patients without PTSD and 3450 patient with PTSD, the association between PTSD and incident type 2 diabetes was not significant after adjusting for obesity. The incidence of type 2 diabetes in patients with PTSD without obesity is similar to that of all adults in the United States.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
The study shows the big impact that factors like smoking, high blood pressure and diabetes can have on the chances of having a heart attack.
While the risk increases for women are bigger than for men, the risk increases for men are still substantial. The study underlines the importance of not smoking and of keeping blood pressure and diabetes under control, for both women and men.
Diet interventions have suggested an association between plant-based diets and improvements in psychological well-being, quality of life and glycated hemoglobin (HbA1c) control in populations with diabetes. The aims of this review are to systematically analyze the available literature on plant-based diet interventions targeting diabetes in adults and to clearly define the benefits on well-being of such interventions. Open Access Article
The Point Project is an initiative between the two organisations: D-Foot International and the International Federation of Podiatrists (FIP-IFP). Both organisations promote the role of evidence-based foot care for patients with and at risk of diabetes. This collaborative work highlights the podiatric skills needed in order to deliver comprehensive evidence-based care to patients with diabetic foot disease. The statements along with the relevant skills and behaviours are based upon the guidance documents produced by the International Working Group on the Diabetic Foot (IWGDF), thus meaning while this is a consensus document it is also evidence-based. To read the full article, log in using your MPFT NHS OpenAthens details.
Open access. Type 2 diabetes (T2DM) is increasing in prevalence worldwide, and is closely linked to obesity. Binge Eating Disorder (BED) and Night Eating Syndrome (NES) are eating disorders that are common in obesity, and may affect the management as well as long term outcomes of T2DM. Therefore, the aim of this review was to assess the prevalence and associations of BED or NES in adults with T2DM.
A healthy diet is likely to improve diabetes control, but this study does not show convincingly that a vegan diet is superior to other healthy diets for people with diabetes. And you don't have to go vegan to improve the quality of your diet.
Treatment with most antipsychotics is associated with an increased risk of weight gain and metabolic disturbances. In a randomized trial, we previously demonstrated that 16 weeks of glucagon‐like peptide‐1 receptor agonist liraglutide treatment vs. placebo significantly reduced glucometabolic disturbances and body weight in prediabetic, overweight/obese schizophrenia‐spectrum disorder patients treated with clozapine or olanzapine. The aim of this study was to investigate whether the beneficial effects of the 16‐week intervention were sustained beyond the intervention period.. To read the full article, log in using your MPFT NHS OpenAthens details.
This study examines if YKL‐40 is increased in individuals with psychotic disorders and if elevated YKL‐40 levels at baseline is associated with subsequent development of type 2 diabetes.. To read the full article, log in using your MPFT NHS OpenAthens details.
Gestational diabetes mellitus (GDM), gestational hypertension (GH) and pre-eclampsia (PE) are associated with short and long-term health issues for mother and child; prevention of these complications is critically important. This study aimed to perform a systematic review and meta-analysis of the relationships between prenatal exercise and GDM, GH and PE. To read the full article, log in using your NHS OpenAthens details.
Translational Issues in Psychological Science; Washingon Vol. 4, Iss. 3, (Sep 2018): 215-227.
Problems with adherence are common among adolescents with Type 1 diabetes (T1D), who must follow a complex treatment regimen. Positive psychology interventions increase adherence and improve health outcomes in adults with chronic conditions; however, they have not been translated to pediatric populations. We evaluated the acceptability and feasibility of Check It!, a positive psychology intervention to improve adherence in adolescents with T1D.. To read the full article, log in using your NHS OpenAthens details.
As part of the development of the NHS Diabetes Prevention Programme, NHS England consulted on the potential to use remote and digital technologies in the new service specification to enable the programme to offer greater uptake and access for service users (in May/June 2018) and these documents are the summaries of the results from the consultation.
Type 1 diabetes mellitus rates are rising worldwide. The health benefits of physical exercise in this condition are many, but more than 60% do not participate, mainly from fear of hypoglycemia. This systematic review explores the effects of physical exercise modes on blood glucose levels in adults for hypoglycemia prevention. Open Access Article
Peer support has been suggested as a promising approach for diabetes management. No conclusive evidence exists on the effects of peer support on self‐efficacy and quality of life in adults with type 2 diabetes.. To read the full article, log in using your MPFT NHS OpenAthens details.
A growing number of clinical trials have shown that home use of hybrid closed-loop insulin delivery systems reduces time spent in hypoglycaemia and improves time in target ranges for those with type 1 diabetes.1, 2, 3, 4, 5, 6 In September, 2016, the first commercially available hybrid closed-loop insulin delivery system for management of type 1 diabetes was approved by the US Food and Drug Administration for patients aged 15 years and older. Approval of this system was supported by a non-randomised trial in which the primary outcome was safety.5, 6 Yet, evidence on use of these systems in preadolescents falls short,7, 8 as does the inclusion of patients with suboptimal glycaemic control..... Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
The achievement of glycaemic control remains challenging for patients with type 1 diabetes. We assessed the effectiveness of day-and-night hybrid closed-loop insulin delivery compared with sensor-augmented pump therapy in people with suboptimally controlled type 1 diabetes aged 6 years and older.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
There is a direct relationship between bodyweight and risk of diabetes. Lorcaserin, a selective serotonin 2C receptor agonist that suppresses appetite, has been shown to facilitate sustained weight loss in obese or overweight patients. We aimed to evaluate the long-term effects of lorcaserin on diabetes prevention and remission.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Our position statement brings together in a simple, unified pathway the currently available technology for people with Type 1 diabetes to manage glucose levels.
Diabulimia has become a common term used to describe a condition when a person with type 1 diabetes has an eating disorder. The individual may omit or restrict their insulin dose to lose/control weight. Evidence suggests that as many as 20% of women with type 1 diabetes may have this condition. To read the full article, log in using your MPFT NHS OpenAthens details.
Objective:
To evaluate the role of platelet-rich plasma (PRP) in healing diabetic fool ulcers (DFUs), and to compare the rate of healing and final outcome with conventional therapy. To read the full article, log in using your MPFT NHS OpenAthens details.
People living with a learning disability have a disproportionately higher risk of developing type 2 diabetes. Susan Smith and Anne Phillips discuss the reasonable adjustments that can be made to improve care for this group of individuals. To read the full article, log in using your MPFT NHS OpenAthens details.
Diabulimia has become a common term used to describe a condition when a person with type 1 diabetes has an eating disorder. The individual may omit or restrict their insulin dose to lose/control weight. Evidence suggests that as many as 20% of women with type 1 diabetes may have this condition. To read the full article, log in using your NHS OpenAthens details.
A 15-year-old boy with type 1 diabetes mellitus presented with a 4-month history of an itchy, erythematous rash confined to the site of his continuous glucose monitoring sensor (CGMS) device (figure 1). CGMS had been initiated following problems with nocturnal hypoglycaemia. Information obtained from the manufacturer confirmed that the adhesive in the dressing contained cyanoacrylate. Patch testing showed a positive reaction to ethyl cyanoacrylate …. To read the full article, log in using your NHS OpenAthens details.
The risk of ischaemic heart disease (IHD) death in early type 1 diabetes onset was assessed using death certification data in Yorkshire.. To read the full article, log in using your NHS OpenAthens details.
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This study adds to evidence that keeping healthy during pregnancy, with a good diet and plenty of exercise, can give the baby a head start when it comes to its own health.
There's a pervasive myth that women need to "eat for 2" while pregnant, but that's not true.
Open access. The increased prevalence of disturbed eating behaviors (DEB), depression, and anxiety in type 1 diabetes (T1D) is generally well established; however the majority of existing research to date has focused on female adolescents and young adults. Data on males and older females is scarce. The aim of this study was to assess prevalence of DEB and symptoms of depression and anxiety among adult males and females with type 1 diabetes, to investigate differences between individuals scoring below and above the cut-off on psychopathology, and to examine patterns of eating disorder psychopathology by age and weight.
it is very important that healthcare providers are aware of the possible risks that could happen during the Hajj. People with diabetes may face many health hazards during the Hajj, including but not limited to the ‘killer triad’: hypoglycemia, foot injury and infections. Many precautions are necessary in the prevention and treatment of possible serious complications. Risk stratification, medication adjustments, proper clinical assessment, and education before doing the Hajj are crucial. Open Access Article
Created an app which is designed to give people with learning disabilities a simple, fun and interactive way to learn about sugar levels in food and healthier alternatives.
Depression often goes hand in hand with a diabetes diagnosis, but mental health support is sorely lacking. More than six out of ten people with diabetes sometimes or often feel down due to the long-term condition, according to Diabetes UK. To read the full article, log in using your MPFT NHS OpenAthens details. SSOTP (legacy account) - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
People with type 1 diabetes are at elevated risk of mortality and cardiovascular disease, yet current guidelines do not consider age of onset as an important risk stratifier. We aimed to examine how age at diagnosis of type 1 diabetes relates to excess mortality and cardiovascular risk.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Open access. Schizophrenia (SCZ) is associated with increased risk of type 2 diabetes (T2D). The potential diabetogenic effect of concomitant application of psychotropic treatment classes in patients with SCZ has not yet been evaluated. The overarching goal of the Genetic Overlap between Metabolic and Psychiatric disease (GOMAP) study is to assess the effect of pharmacological, anthropometric, lifestyle and clinical measurements, helping elucidate the mechanisms underlying the aetiology of T2D.
Compared with cognition‐focused diabetes care for adults with type 2 diabetes mellitus, emotion‐cognition‐focused diabetes care had no clear impact on overall diabetes‐related distress, self‐efficacy, health‐related quality of life, HbA1c level, systolic or diastolic blood pressure, or adverse events.
Clinicians can match people with type 2 diabetes to the right drug to improve control of blood sugar and help avoid damaging side-effects, simply by factoring in characteristics such as sex and BMI into prescribing decisions, new MRC-funded research suggests.
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This article describes a study of the phenomenon of supporting patients who are learning to live with diabetes, from a diabetes specialist nurse (DSN) perspective. To read the full article, log in using your NHS OpenAthens details.
In an unadjusted analysis each 2000-step increment in the average number of daily steps, up to 10 000, was associated with a 5.5% lower risk of progression to diabetes. Open Access Article
The NHS Diabetic Eye Screening Programme produced this guidance in response to queries from local screening providers.
Providers should use this guidance to inform local policy on dealing with patients who drive to their screening appointment.
To test the hypothesis that fluid adherence in patients on hemodialysis can be improved through nurses′ solution‐focused communication with patients on issues of adherence.. To read the full article, log in using your MPFT NHS OpenAthens details. SSOTP (legacy account) - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
There is a growing body of evidence that supports the uses of telehealth to monitor and manage people with diabetes at a distance. Despite this, the uptake of telehealth has been low. The objective of this study is to explore patients’ perceptions of using telehealth for type 2 diabetes management in a group of NHS patients in London.
To examine the relationships of health literacy to diabetes self‐care behaviors (diet, physical exercise, foot care and blood glucose monitoring) through empowerment controlling for diabetes education.. To read the full article, log in using your MPFT NHS OpenAthens details. SSOTP (legacy account) - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
There is only limited and conflicting evidence on the effectiveness of Pay-for-Performance (P4P) programmes, although they might have the potential to improve guideline adherence and quality of care. We therefore aim to test a P4P intervention in Swiss primary care practices focusing on quality indicators (QI) achievement in the treatment of patients with diabetes.
Open Access Article
Conclusions: Patients in the BCBH-D program experienced reduced all-cause health care utilization and costs. Direct cost savings were US $815. Although encouraging, given the complexity of the patient population, further study is needed to cross-validate the results.
With the rise in pre-mature mortality rate from non-communicable disease (NCD), there is a need for evidence-based interventions. We evaluated existing systematic reviews on effectiveness of integration of healthcare services, in particular with focus on delivery of care designed to improve health and process outcomes in people with multi-morbidity, where at least one of the conditions was diabetes or hypertension.
There is a growing body of evidence to support the use of telehealth in monitoring HbA1c levels in people living with type 2 diabetes. However, the overall magnitude of effect is yet unclear due to variable results reported in existing systematic reviews. The objective of this study is to conduct a systematic review and meta-analysis of systematic reviews of randomised controlled trials to create an evidence-base for the effectiveness of telehealth interventions on glycemic control in adults with type 2 diabetes.
Genome-wide association studies have implicated around 250 genomic regions in predisposition to type 2 diabetes, with evidence for causal variants and genes emerging for several of these regions. Understanding of the underlying mechanisms, including the interplay between β-cell failure, insulin sensitivity, appetite regulation, and adipose storage has been facilitated by the integration of multidimensional data for diabetes-related intermediate phenotypes, detailed genomic annotations, functional experiments, and now multiomic molecular features.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past 25 years, resulting in a broad understanding about many aspects of the disease, including its genetics, epidemiology, immune and β-cell phenotypes, and disease burden.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
While these findings warrant further study, they are not proof that titanium dioxide causes diabetes. With so few samples tested, any differences between samples with and without diabetes could be due to chance.
Even if it is confirmed that levels of titanium dioxide are higher in people with diabetes, this doesn't necessarily mean titanium dioxide caused the condition.
And even if future evidence suggests titanium dioxide may be a risk factor for diabetes, there is no evidence that toothpaste is to blame.
Dietary factors are of paramount importance in the management and prevention of type 2 diabetes. Despite progress in formulating evidence based dietary guidance, controversy and confusion remain. In this article, we examine the evidence for areas of consensus as well as ongoing uncertainty or controversy about dietary guidelines for type 2 diabetes.
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Compared with usual care for people with diabetes (mostly adults with type 2 diabetes attending primary care settings in the USA or in Europe), low-quality evidence suggests that interventions targeted at screening for diabetic retinopathy or improving the quality of diabetes care increased the number of people attending diabetic retinopathy screening across a 12-month follow-up period
Luton’s GP practices responded extremely positively to the NHS Diabetes Prevention Programme (NHS DPP) with impressive engagement and high rates of referral from every practice. More than 3,000 adults with non-diabetic hyperglycaemia, representing over 2% of Luton’s adult population, were referred to the programme in its first 6 months.
Free access. To determine the cross‐sectional and longitudinal associations between diabetes treatment type and cognitive outcomes among type II diabetics.
When adults (mean age 45 to 63 years) with impaired glucose tolerance and at risk of developing type 2 diabetes mellitus undertook diet plus exercise programs aimed at achieving a 5% to 7% weight loss, or a loss of 2.5 kg, moderate-quality evidence shows that fewer people went on to develop type 2 diabetes than adults receiving standard advice and education
How to optimise the NHS Diabetes Prevention Programme in order to identify those at risk of Type 2 diabetes and help lower their risk of developing the disease.
A large proportion of the Muslim population fasts during Ramadan. The risk of hypoglycemia is increased with fasting during Ramadan in people with diabetes who are on insulin and insulin secretagogues. Therefore, the combination of fasting with diabetes and driving presents a challenging situation, with legal implications for such individuals and their healthcare professionals. This novel, narrative, non-systematic review discusses the importance of addressing hypoglycemia in fasting with reference to secular legal guidance on driving with diabetes. We discuss religious aspects relating to fasting and driving in Islam. While there is no clear guidance or legal position on diabetes and driving for individuals who are fasting, Islamic law provides a logical framework to address this. Open Access Article
People with severe mental illnesses (SMI) such as schizophrenia and bipolar disorder have an increased risk of developing type 2 diabetes and have poorer health outcomes than those with diabetes alone. To maintain good diabetes control, people with diabetes are advised to engage in several self-management behaviours. The aim of this study was to identify barriers or enablers of diabetes self-management experienced by people with SMI.
Editorial. Login at top right hand side of page using your MPFT NHS OpenAthens for full text. SSOTP (legacy account)- Please contact the library to receive a copy of this article - http://bit.ly/1Xyazai
To synthesize the effects of Internet empowerment‐based self‐management interventions on adults with metabolic diseases.. To read the full article, log in using your SSSFT NHS OpenAthens details. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Social comparisons (ie, self-evaluation in comparison with others) influence patients’ perspectives of their disease and may impact motivation and health behavior; however, little is known about patients’ perspectives toward receiving such information in a clinical context (eg, from their doctor’s office or health system). This study aims to understand patients’ perspectives and anticipated responses to receiving social comparison information regarding measures of their diabetes-related health status (eg, A1C) and how receiving such information would compare with goal-based comparisons (ie, self-evaluation in comparison with goal). Open Access Article
Up to 30 GP surgeries in the county will benefit from a pilot scheme which helps people suffering from diabetes to manage and improve their mental health.
Lincolnshire Partnership NHS Foundation Trust (LPFT) is offering talking therapies to selected patients who are identified as requiring support to control their diabetes.
Among individuals at high risk for diabetes identified through a population survey, we performed an intervention study with basic lifestyle advice aiming to prevent diabetes.
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Since 2016, the NHS has begun testing new services which integrate mental and physical treatments, as part of its Improving Access to Talking Therapies programme. People with long-term health issues like diabetes, heart problems or respiratory illness are now routinely given a ‘whole-person assessment’, focusing on what additional mental health care they may need to manage their condition.
Diabetes UK's revised nutrition guidelines for the prevention and management of diabetes, published recently, encourage education in self-management and include additional guidance for older people with diabetes. The incidence of diabetes in older people is increasing. Many older people with diabetes are healthy and mobile, and live in the community, but a number are frail and living in care homes. Those who are frail are at increased risk of malnutrition from a range of causes. Older people with diabetes should be assessed for malnutrition risk and referred to a dietitian if required. Management of these patients focuses on foods that are high in protein and energy foods. A case study gives an example of how a community nurse may be involved.
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Using primary care data obtained from the UK Clinical Practice Research Datalink, this retrospective cohort study examined the relationships between medication adherence and clinical outcomes in patients with type 2 diabetes. Open Access Article
Open access. The combination of eating disorders and diabetes is associated with increased risk of morbidity and mortality. The aim of this study is to compare the prevalence of disordered eating behaviour (DEB) in young adults with type 1 diabetes mellitus to a sample of non-diabetic controls, and to examine the relationship of DEB to glycaemic control.
Around 27,500 Staffordshire patients who are at risk of developing Type 2 Diabetes are being urged to make changes to their lifestyle to reverse that risk during Diabetes Prevention Week.
The Diabetes Foot Care Profiles present Clinical Commissioning Group (CCG) level information regarding people with diabetes who were admitted to hospital for foot disease.
The profiles include a range of analysis covering risk, treatment and outcomes, highlighting any variations between areas. They are intended to help guide equitable national, regional and local commissioning of diabetic foot care services and other preventative interventions.
Families, Systems, & Health Vol. 36, Iss. 1, (Mar 2018): 87-96.
Introduction: Spousal support is one of the strongest and most consistent predictors of Type 2 diabetes treatment adherence. However, the effects of both spouses’ evaluations of dyadic coping on emotional distress and patients’ physical health remain largely unknown.. To read the full article, log in using your NHS OpenAthens details.
Very few real-world studies have been conducted to assess the incidence of diabetes-related hypoglycemia. Moreover, there is a paucity of studies that have investigated hypoglycemia among people taking secretagogues as a monotherapy or in combination with insulin. Accordingly, our research team developed and validated the InHypo-DM Person with Diabetes Mellitus Questionnaire (InHypo-DMPQ) with the aim of capturing the real-world incidence of self-reported, symptomatic hypoglycemia.
Open Access Article
Conclusions: There is a high prevalence of stigma in youth with type 1 diabetes that is associated with both elevated HbA1c levels and severe hypoglycemia. Targeted strategies to address stigma are needed.
Based on a growing body of epidemiological and biomedical studies, physical activity (PA) is considered a cornerstone in type 2 diabetes treatment. However, it is also a practice embedded in daily life and, as such, may produce certain frictions as a topic in health care. The aim of this article is to give in-depth insight into experiences of health care professionals with the delivery of PA counselling to people with type 2 diabetes.
Open access. To investigate associations between takeaway meal consumption and risk markers for coronary heart disease, type 2 diabetes and obesity risk markers in children.
Having established proof of the concept behind the device in a study published in Nature Nanotechnology, the research team from the University of Bathopens in new window hopes that it can eventually become a low-cost, wearable sensor that sends regular, clinically relevant glucose measurements to the wearer’s phone or smartwatch wirelessly, alerting them when they may need to take action.
An important advantage of this device over others is that each miniature sensor of the array can operate on a small area over an individual hair follicle – this significantly reduces inter- and intra-skin variability in glucose extraction and increases the accuracy of the measurements taken such that calibration via a blood sample is not required.
The study, which received funding from the MRC and was an international collaboration with King’s College London, University of Oxford, MRC Harwell, University of California in Los Angeles, University of Pennsylvania and others, examined the effect of a gene called KLF14. The researchers found that genetic variations that control KLF14 were associated with where in the body excess fat was stored. In women, versions of the gene that result in fat being stored around the hips, rather than the abdomen, were linked to a lower risk of diabetes.