“BRAINS” encapsulates the higher-level principles to think about relating to the proposed drug, the patient and their condition (use your BRAINS: Benefits, Risks, Adverse Effects, Interactions, Necessary prophylaxis, Susceptibilities) before prescribing and “AIMS”, the action principles around prescribing/giving the drug (AIMS: Administering, Informing, Monitoring and Stopping). To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Aim: To summarise the effectiveness of organisational interventions on appropriate opioid prescribing for non-cancer pain upon hospital discharge. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Poor adherence to allopurinol among people with gout contributes to suboptimal gout management. This study sought to understand the facilitators and barriers to allopurinol adherence across the three stages of medication adherence, and patient perspectives on strategies to improve adherence. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study utilized physiologically based pharmacokinetic (PBPK) and pharmacodynamic (PD) modeling to further examine the underlying mechanisms of anxiety treatment and addiction. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Drug shortage is a growing global health issue. The aim of the study was to evaluate the consequences of drug shortages on patient safety based on data recorded in the French Pharmacovigilance Database. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The aim of this study was to systematically review whether concurrent treatment with an SSRI and low-dose ASA increases the risk of bleeding compared with treatment with an SSRI alone or ASA alone. Open access article - no login required.
From 1 April 2019 pregabalin and gabapentin will be reclassified as class C controlled substances in the UK. The change, announced in October 2018, is expected to prompt a decline in the use of the drugs as prescribing, dispensing, and collecting them becomes more onerous for doctors, pharmacists, and patients. To read the full article, log in using your NHS OpenAthens details.
Editorial. . To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
Antipsychotic use appears to increase mortality risk among older adults with dementia. Whether this risk is similar for regular or intermittent use is unknown. This scoping review aims to explore the temporal association between antipsychotic use and mortality risk for older institutionalized adults.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
One of the most exciting recent breakthroughs from research funded by the National Institute of Mental Health, or NIMH, is the development of a fast-acting medication for treatment-resistant depression based on ketamine
Prescribers should be alert for neuropsychiatric reactions in patients taking montelukast and carefully consider the benefits and risks of continuing treatment if they occur.
To evaluate the effects of once‐daily valbenazine (40 or 80 mg/day) in older and younger adults with tardive dyskinesia (TD).. To read the full article, log in using your MPFT NHS OpenAthens details.
This review is an abridged version of a Cochrane review previously published in the Cochrane Database of Systematic Reviews, 2018, April 10, Issue 4. To read the full article, log in using your MPFT NHS OpenAthens details.
Ketamine has been documented for its rapid antidepressant effects. However, optimal dose and delivery route have not yet been thoroughly investigated. The objectives of this study were to document the safety and test the antidepressant and antisuicidal effects of a single rapid 1-minute injection of ketamine 0.5 mg/kg in treatment-resistant depression (TRD). . MPFT staff can use the OVID link, or you can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Observational studies show an association between nightmares and suicide. Prazosin is proposed as a nightmare treatment. This pilot, randomized clinical trial tested whether treatment of nightmares with prazosin would reduce suicidal ideas in suicidal posttraumatic stress disorder (PTSD) patients. . MPFT staff can use the OVID link, or you can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Why you should read this article:
> To enhance your understanding of the pharmacological interventions that can be used in people with dementia, ensuring appropriate and effective care for these patients
> To be aware of the challenges and cautions associated with medicines administration in people with dementia, thus supporting patient safety
> To count towards revalidation as part of your 35 hours of CPD, or you may wish to write a reflective account (UK readers)
> To contribute towards your professional development and local registration renewal requirements (non-UK readers)
To read the full article, log in using your MPFT NHS OpenAthens details.