To describe paracetamol dosing and liver function test (LFT) monitoring in older hospital inpatients who are frail or have low body weight. To read the full article, log in using your NHS OpenAthens details.
This systematic analysis aimed to characterize the available DDDI trials with immunomodulatory drugs, experimental evidence for a DDDI risk, and reported DDDI risk information in FDA/EMA approved drug labelling. To read the full article, log in using your NHS OpenAthens details.
Measuring adherence to medication is complex due to the diversity of contexts in which medications are prescribed, dispensed, and used. The Timelines-Events-Objectives-Sources (TEOS) framework outlined a process to operationalize adherence. To read the full article, log in using your NHS OpenAthens details.
This systematic review assesses the evidence that ketamine significantly reduces refractory anxiety and discusses to what extent this may be mediated by NMDA receptor antagonism and other receptors. To read the full article, log in using your NHS OpenAthens details.
The urgent need for appropriate treatment for suicide, the tenth leading cause of death, has led to numerous studies. This study aims to systematically identify and appraise systematic reviews with or without meta-analyses investigating ketamine in suicidal ideation and behaviors. To read the full article, log in using your NHS OpenAthens details.
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare, drug-induced severe adverse reaction that usually occurs 3-6 weeks after initial exposure to certain drugs. To read the full article, log in using your NHS OpenAthens details.
The gabapentinoids were reclassified as Schedule II medications and Class C drugs in the UK in 2019 due to their misuse potential. In this study we examined deaths following gabapentinoid use in England reported to the National Programme on Substance Abuse Deaths. To read the full article, log in using your NHS OpenAthens details.
This article highlights practical considerations in the initiation, switching and discontinuation of biologics in the management of JIA. To read the full article, log in using your NHS OpenAthens details.
Why you should read this article:
To identify medicines that can precipitate or cause falls, as well as those that can increase the risk of fall-related injuries
To understand the importance of including medication reviews as part of falls prevention strategies
To consider actions you could take in your practice to prevent medicines-related falls in older people
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Schizophrenia is associated with poor anticoagulation control and clinical prognosis in patients with atrial fibrillation (AF). Little is known about initiation of oral anticoagulation therapy (OAC) in this patient population. To read the full article, log in using your NHS OpenAthens details.
To explore the level of agreement on drug-drug interaction (DDI) information listed in three major online drug information resources (DIRs) in terms of: (1) interacting drug pairs; (2) severity rating; (3) evidence rating and (4) clinical management recommendations. To read the full article, log in using your NHS OpenAthens details.
Here, we report the results from a phase 1 study to evaluate the safety, tolerability and pharmacokinetics of TAK-041 in healthy adults and exploratory efficacy assessment of TAK-041 as adjunctive therapy to antipsychotics in adults with stable schizophrenia. To read the full article, log in using your NHS OpenAthens details.
Dose banding is a method of dose individualisation in which all patients with similar characteristics are allocated to the same dose. This study aims to explore the effects of dose banding on therapeutic success and failure. To read the full article, log in using your NHS OpenAthens details.
A few studies suggested that epilepsy and antiepileptic drugs with sodium channel blocking properties were independently associated with out-of-hospital cardiac arrest (OHCA). However, these findings have not yet been replicated.
This study calculated the medication costs of PIP and created alternative prescribing scenarios for the 22 PROMPT criteria. To read the full article, log in using your NHS OpenAthens details.
To investigate the effects of a comprehensive medication review intervention on health-related quality of life (HRQoL) and clinical outcomes in geriatric outpatients exposed to polypharmacy. To read the full article, log in using your NHS OpenAthens details.
Palindromic rheumatism (PR) is characterized by self-resolving and short duration attacks of arthritis/periarthritis. The present study was performed to report the results of PR treatment with methotrexate (MTX). To read the full article, log in using your NHS OpenAthens details.
Previous studies have suggested that some medications may influence dementia risk. We conducted a hypothesis-generating medication-wide association study to investigate systematically the association between all prescription medications and incident dementia. To read the full article, log in using your NHS OpenAthens details.
Filgotinib is a potent, oral, JAK1-preferential inhibitor for the treatment of rheumatoid arthritis (RA). This report describes exposure-response (ER) analyses of filgotinib for dose confirmation based on three Phase 3 and two Phase 2 studies in moderate to severe RA patients. To read the full article, log in using your NHS OpenAthens details.
In our report, we describe a case of acute refractory NCSE in the context of a TCC-induced acute toxic encephalopathy (ATE) in a woman without any previous neurological or physical comorbidities. To read the full article, log in using your NHS OpenAthens details.