The authors assessed the efficacy, safety, and tolerability of MIN-101, a compound with affinities for sigma-2 and 5-HT2A receptors and no direct dopamine affinities, in comparison with placebo in treating negative symptoms in stabilized patients with schizophrenia. Login at top right hand side of page using your SSSFT NHS Athens for full text.
This meta-analysis compares the multiple pharmacologic combination strategies that have been studied for suboptimal treatment responses in schizophrenia....Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
The onset of schizophrenia occurs during a period critical for development of social relationships and functional independence. As such, interventions that target the early course of illness have the potential to stave off functional decline and restore functioning to pre-illness levels. In this entirely remote study, people with recent-onset schizophrenia spectrum disorders (SSDs) participated in a 12-week randomized controlled trial to determine the efficacy of PRIME (personalized real-time intervention for motivational enhancement), a mobile-based digital health intervention designed to improve motivation and quality of life.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
A digital dashboard showing daily updates of progress against the new access and waiting time standard for Early Interventional in Psychosis (EIP) is helping improve outcomes in Berkshire.
ECT remains an important, yet underutilized, treatment for schizophrenia. Recent research shows that medication-resistant patients with schizophrenia, including those resistant to clozapine, respond well to ECT augmentation. The purpose of this article is to review recent studies of the use of ECT in the treatment of schizophrenia. . SSSFT staff can use the OVID link, or you can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
This population-based study compares psychiatric hospital readmission in patients with severe affective disorders based on receipt of electroconvulsive therapy.....Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Our primary objective was to assess the effects (benefits and harms) of ECT for people with treatment-resistant schizophrenia.. Please contact the library to request a copy of this article - http://bit.ly/2HjNDf3
Antipsychotics produce electroencephalogram (EEG) modifications and increase the risk of epileptic seizure. These modifications remain sparsely studied specifically for atypical antipsychotics. In this context, our study focuses on EEG modifications associated with atypical strict antipsychotic monotherapies. . MPFT staff can use the OVID link, or you can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Although most individuals with severe mental illness such as schizophrenia are neither antisocial nor violent, the risk of committing a homicide for people with schizophrenia is higher than that for those in the general population.1 Thus, a paradox typifies many psychiatric conditions for which a specific disorder is associated with increased risk of violence, despite a low prevalence of violence among those with the disorder. Seena Fazel and colleagues'2 new study in The Lancet Psychiatry seeks to clarify this paradox by identifying low risk of committing violent crime among a national cohort of 75 158 Swedish individuals......Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Schizophrenia is a severe psychiatric disorder of complex etiology. Immune processes have long been proposed to contribute to the development of schizophrenia, and accumulating evidence supports immune involvement in at least a subset of cases. In recent years, large-scale genetic studies have provided new insights into the role of the immune system in this disease. Here, we provide an overview of the immunogenetic architecture of schizophrenia based on findings from genome-wide association studies (GWAS).. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Previous research has shown that empathy for pain is disrupted at the neural level in people with schizophrenia. However, many of these studies have failed to assess key background contextual variables that have previously been linked to neurophysiological responding. Moreover, no study to date has examined the potential influence of schizotypal characteristics on neurophysiological responding in non‐clinical individuals.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
Previous research has shown that empathy for pain is disrupted at the neural level in people with schizophrenia. However, many of these studies have failed to assess key background contextual variables that have previously been linked to neurophysiological responding. Moreover, no study to date has examined the potential influence of schizotypal characteristics on neurophysiological responding in non‐clinical individuals.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
In the era of deinstitutionalization, employment was an uncommon outcome for people with schizophrenia and other severe mental illnesses living in the community.1 Mental health and vocational rehabilitation professionals initially offered little help, perhaps because they believed that people with severe mental illnesses were unable or unlikely to work competitively. Instead, professionals referred people coming out of hospitals to sheltered settings, such as day programs and sheltered workshops, where they could be monitored closely and trained to work in a slow, step-wise fashion. Even the Program for Assertive Community Treatment2—a pioneer in community integration in the 1970s and 1980s—initially endorsed sheltered work...... Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Diabetes mellitus contributes to excessive cardiovascular deaths and reduced life expectancy in schizophrenia. This population-based cohort study investigated the endogenous risk for diabetes in antipsychotic-naive schizophrenia and evaluated the risks added by starting antipsychotic treatment in people with schizophrenia. : Login at top right hand side of page using your SSSFT NHS Athens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Neuropsychology30.8 (Nov 2016): 998-1008.
Background: Individuals with schizophrenia who engage in targeted cognitive training (TCT) of the auditory system show generalized cognitive improvements. The high degree of variability in cognitive gains maybe due to individual differences in the level of engagement of the underlying neural system target. To read the full article, log in using your NHS OpenAthens details.
Many studies show that people experiencing psychosis find religion and spirituality to be helpful during times of distress, yet nurses often lack training and confidence to respond to the spiritual needs of their patients. This article begins with an overview of the largely medical model through which psychosis is assessed and addressed in the UK, followed by some definitions of spirituality and religion. Then using a case study of Lucy, a 60-year-old African-Caribbean woman, a critical analysis considers if and how engagement with her religious beliefs in an acute inpatient setting could have improved the nurse-patient relationship and promoted recovery from an acute psychotic episode. The impact of task-driven nursing care upon meaningful engagement is explored and nurses are encouraged to focus on quality rather than length of nurse-patient interactions. The association between religiosity and psychopathology is then considered in terms of impact upon person-centred care. The value of co-creating a narrative with patients in order to promote engagement and recovery is discussed. To read the full article, log in using your NHS OpenAthens details.
Supported living has been shown to improve functioning and social inclusion in people with severe and persistent mental health problems, reduce hospitalisation and provide secure accommodation in a population where housing needs are often unmet. Conversely, living in supported accommodation has been depicted by some as depersonalising, marginalising and an ordeal to survive. The present study sought to shed light on the experiences of residents in an enhanced supported living service in the United Kingdom. To read the full article, log in using your NHS OpenAthens details.
This study found higher ethnic density related to lower risk of FEP within the Pakistani population in East Lancashire, highlighting the impact of local social context on psychosis incidence. Open access article - no login required.
Neighbourhood social context might play a role in modifying mortality outcomes in severe mental illness, but has received little attention to date. Therefore, we aimed to assess in an ethnically diverse and urban location the association of neighbourhood-level characteristics and individual-level factors for all-cause, natural-cause, and unnatural-cause mortality in those with severe mental illness.. Please contact the library to request a copy of this article - http://bit.ly/2HjNDf3
Open access. The incidence of psychotic disorders is elevated in some minority ethnic populations. However, we know little about the outcome of psychoses in these populations.