Response. To read the full article, log in using your MPFT NHS OpenAthens details. SSOTP (legacy account) - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
In this response to Bortolotti and Jefferson (2018), we discuss the action‐guidance problem of moral attributes and the risk of superiority illusion in early intervention for psychosis.. To read the full article, log in using your MPFT NHS OpenAthens details. SSOTP (legacy account) - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Accumulating evidence implicates immune activation in the development of schizophrenia. Here, monocyte numbers, monocyte chemoattractant protein‐1 (MCP‐1) and chitinase‐3‐like protein 1 (YKL‐40) were investigated in plasma and cerebrospinal fluid (CSF) in first‐episode psychosis (FEP) patients.. To read the full article, log in using your MPFT NHS OpenAthens details. SSOTP (legacy account) - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Letter. . To read the full article, log in using your MPFT NHS OpenAthens details. SSOTP (legacy account) - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Open access. There is increasing evidence for shared genetic susceptibility between schizophrenia and bipolar disorder. Although genetic variants only convey subtle increases in risk individually, their combination into a polygenic risk score constitutes a strong disease predictor.
Schizophrenia is a severe psychiatric disorder of complex etiology. Immune processes have long been proposed to contribute to the development of schizophrenia, and accumulating evidence supports immune involvement in at least a subset of cases. In recent years, large-scale genetic studies have provided new insights into the role of the immune system in this disease. Here, we provide an overview of the immunogenetic architecture of schizophrenia based on findings from genome-wide association studies (GWAS).. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Free. Acute psychotic illness, especially when associated with agitated or violent behavior, can require urgent pharmacological tranquillization or sedation. In many countries, benzodiazepines (either alone or in combination with antipsychotics) are often used in this situation (1).
From web-based applications to mobile devices, digital technologies hold tremendous potential to facilitate the delivery of healthcare for mental disorders, including schizophrenia. These eHealth (ie, electronic health) tools are increasingly being used to assist consumers during the course of their illnesses, from the provision of the continuity of care to improving well-being.1 This makes sense due to the growing trends of digital tool usage in psychiatric samples. . Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Contrary to the notion that neurology but not psychiatry is the domain of disorders evincing structural brain alterations, it is now clear that there are subtle but consistent neuropathological changes in schizophrenia. These range from increases in ventricular size to dystrophic changes in dendritic spines. A decrease in dendritic spine density in the prefrontal cortex (PFC) is among the most replicated of postmortem structural findings in schizophrenia. Examination of the mechanisms that account for the loss of dendritic spines has in large part focused on genes and molecules that regulate neuronal structure. But the simple question of what is the effector of spine loss, ie, where do the lost spines go, is unanswered.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
The onset of schizophrenia occurs during a period critical for development of social relationships and functional independence. As such, interventions that target the early course of illness have the potential to stave off functional decline and restore functioning to pre-illness levels. In this entirely remote study, people with recent-onset schizophrenia spectrum disorders (SSDs) participated in a 12-week randomized controlled trial to determine the efficacy of PRIME (personalized real-time intervention for motivational enhancement), a mobile-based digital health intervention designed to improve motivation and quality of life.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Immunological abnormalities have been reported in schizophrenia (SZ) for over 5 decades. Interest ebbs and flows, mainly because it is difficult to find a coherent picture. We are in the midst of a renaissance, fueled by reported therapeutic benefits from anti-inflammatory drugs and recent meta-analyses of serologic and genetic data. Still, the problem is daunting because it occurs at the nexus of the immune system and the central nervous system (CNS), two of the most complex organs in humans.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Cognitive impairments and negative symptoms in schizophrenia are associated with poorer outcomes and are typically resistant to pharmacological interventions. However, these features can vary dramatically in their level of expression, and they can improve as a function of external context (by providing performance-contingent incentives and a more stimulating environment) and internal context (by challenging defeatist performance beliefs and by reducing stress and improving physical health). This Open Forum briefly reviews some of this evidence for the situational variability of cognitive impairments and negative symptoms in schizophrenia and highlights psychosocial treatments that capitalize on this variability.. Login at top right hand side of page using your MPFT NHS OpenAthens for full text. SSOTP (legacy account)- Please contact the library to receive a copy of this article - http://bit.ly/1Xyazai
Results: In this study, 84.8% (89/105) of the patients had access to the internet and 88.6% (93/105) owned an electronic internet device. In total, 71.3% (57/80) of patients who owned a mobile phone were interested in eHealth systems and 38.2% (37/97) reported negative experiences related to the internet usage. We observed differences between the groups in terms of device ownership (P=.02), the frequency of internet access (P<.001), the use of social media (P=.01), and seeking health information (P=.04); the differences were found to be higher in the early psychosis grou
Results: In this study, 84.8% (89/105) of the patients had access to the internet and 88.6% (93/105) owned an electronic internet device. In total, 71.3% (57/80) of patients who owned a mobile phone were interested in eHealth systems and 38.2% (37/97) reported negative experiences related to the internet usage. We observed differences between the groups in terms of device ownership (P=.02), the frequency of internet access (P<.001), the use of social media (P=.01), and seeking health information (P=.04); the differences were found to be higher in the early psychosis grou
Second-generation antipsychotics are commonly prescribed to reproductive-age women for the treatment of a spectrum of psychiatric disorders. Quetiapine is the most commonly prescribed medication in this class, and therefore a better understanding of its reproductive safety profile is critical. The goal of this study was to determine the risk of major malformations among infants exposed to quetiapine during pregnancy compared with a group of infants whose mothers had a history of psychiatric morbidity but who did not use a second-generation antipsychotic during pregnancy.. Login at top right hand side of page using your MPFT NHS OpenAthens for full text. SSOTP (legacy account)- Please contact the library to receive a copy of this article - http://bit.ly/1Xyazai
Psychological Medicine; Cambridge Vol. 48, Iss. 12, (Sep 2018): 1993-2000. DOI:10.1017/S0033291717003518
Schizophrenia (SZ) and bipolar disorder (BP) are causes of severe disability worldwide and parents’ severe mental illness (SMI) is associated with childhood adversity, and socio-emotional and cognitive problems in children. Yet, how parental BP and SZ affect educational attainment in offspring is still unclear.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Psychological Medicine; Cambridge Vol. 48, Iss. 12, (Sep 2018): 1966-1974. DOI:10.1017/S0033291717003488
Background. Acting on harmful command hallucinations is a major clinical concern. Our COMMAND CBT trial approximately halved the rate of harmful compliance (OR = 0.45, 95% CI 0.23–0.88, p = 0.021). The focus of the therapy was a single mechanism, the power dimension of voice appraisal, was also significantly reduced. We hypothesised that voice power differential (between voice and voice hearer) was the mediator of the treatment effect.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Psychological Medicine; Cambridge Vol. 48, Iss. 12, (Sep 2018): 1925-1936. DOI:10.1017/S003329171700383X
Schizophrenia and other types of psychosis incur suffering, high health care costs and loss of human potential, due to the combination of early onset and poor response to treatment. Our ability to prevent or cure psychosis depends on knowledge of causal mechanisms. Molecular genetic studies show that thousands of common and rare variants contribute to the genetic risk for psychosis. Epidemiological studies have identified many environmental factors associated with increased risk of psychosis. However, no single genetic or environmental factor is sufficient to cause psychosis on its own.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Open access. To investigate the frequency of childhood and adult attention deficit hyperactivity disorder (ADHD) symptoms in a cohort of patients with schizophrenia (SCZ).
Cognitive reserve (CR) refers to the brain's capacity to cope with pathology in order to minimize the symptoms. CR is associated with different outcomes in severe mental illness. This study aimed to analyze the impact of CR according to the diagnosis of first‐episode affective or non‐affective psychosis (FEP).. To read the full article, log in using your MPFT NHS OpenAthens details. SSOTP (legacy account) - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.