Our aim was to investigate whether early detection was feasible in prison and whether it could improve mental health outcomes in young prisoners. A secondary aim was to explore whether it can reduce returns to prison. Between 2011 and 2014, a total of 2115 young prisoners were screened, 94 (4.4%) met criteria for ultra-high risk for psychosis and were offered an intervention, 52 actually received it. Return to prison data were sought on the 52 participants, receiving a formal intervention.....Login using your SSSFT NHS OpenAthens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Research and clinical translation in schizophrenia is limited by inconsistent definitions of treatment resistance and response. To address this issue, the authors evaluated current approaches and then developed consensus criteria and guidelines. Login at top right hand side of page using your SSSFT NHS Athens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
The study, funded by the MRC and published in Nature Communications, suggests that being genetically programmed to rise early may lead to greater well-being and a lower risk of schizophrenia and depression. However, despite much previous speculation, the results did not reveal any strong links to diseases such as diabetes or obesity.
Open access. Cardiometabolic health significantly impacts on the mortality of people with severe mental illness. Clozapine has the greatest efficacy for Treatment Resistant Schizophrenia (TRS) but the greatest negative impact on cardiometabolic health. Balancing the risks and benefits of treatment, dignity, autonomy, liberty, mental and physical health can be challenging, particularly when imposing interventions with potentially life threatening adverse events, such as clozapine. We describe the successful administration of clozapine in the face of myocardial infarction, pulmonary embolism and hyperlipidaemia resulting in the termination of long-term seclusion for a gentleman with TRS in high secure psychiatric services.
Holt et al show that a lifestyle intervention did not reduce weight in people with schizophrenia. The STEPWISE trial casts a critical focus on the challenges of improving physical health in people with schizophrenia. The trial underpins efforts to maintain momentum in overcoming the unacceptable health inequalities in this population.. To read the full article, log in using your MPFT NHS OpenAthens details.
Editorial. As someone who has studied the behavioral and neurological effects of intensive, targeted auditory training in schizophrenia and who confronts the realities of cognitive dysfunction weekly in my clinical work with patients, I find myself having three different responses to this article. My first response, that of a clinical trialist, is admiration: this really is an elegant and well-conducted study. My second response, that of a clinician, is excitement mingled with impatience: more than 25 years ago, Michael Green (2) challenged us in this very journal to make cognitive remediation a standard treatment for schizophrenia. So why is it taking us so long to get there? And my third response, that of a researcher, includes questions about the perceptual training component of this study and what conclusions we can draw, if any, regarding the usefulness (or nonusefulness) of addressing lower-level sensory processing deficits in schizophrenia spectrum disorders...... Login at top right hand side of page using your MPFT NHS OpenAthens for full text.
Psychotic symptoms may occur in any dementia, including Alzheimer’s disease (AD), but are particularly common in Lewy body dementia (LBD). The mechanisms of psychotic symptoms are largely unknown. Psychosis has been found to be associated with more severe AD and Lewy body pathology in patients with AD and cerebrovascular disease-related vasculopathy.1 One form of vascular pathology, cerebral amylod angiopathy (CAA), is defined as deposits of amyloid in the vessel walls that increase risk of haemorrhage and ischaemia. CAA contributes to neurodegeneration, but its relation to clinical symptoms and course in dementia is not fully understood.2. To read the full article, log in using your NHS OpenAthens details.
Cortical thickness reductions in schizophrenia are irregularly distributed across multiple loci. The authors hypothesized that cortical connectivity networks would explain the distribution of cortical thickness reductions across the cortex, and, specifically, that cortico-cortical connectivity between loci with these reductions would be exceptionally strong and form an interconnected network. This hypothesis was tested in three cross-sectional schizophrenia cohorts: first-episode psychosis, chronic schizophrenia, and treatment-resistant schizophrenia.. Login at top right hand side of page using your MPFT NHS OpenAthens for full text.
Commentary. People with severe mental illness have higher mortality rates, culminating in about 20 years of lost life compared with that of the general population, and momentum is growing to reduce this inequality.1, 2 In the general population, neighbourhood social context is related to mortality, but whether such patterns also exist for people with severe mental illness has received little attention. Understanding this relationship could allow us to tailor social interventions for this distinctive population. The study by Jayati Das-Munshi and colleagues3 in The Lancet Psychiatry represents a welcome step in that direction, linking higher neighbourhood ethnic density to lower mortality rates among people with severe mental illness from ethnic minority backgrounds. These results raise the intriguing possibility that factors associated with ethnic density might promote longevity among people with severe mental illness.. Please contact the library to request a copy of this article - http://bit.ly/2HjNDf3
The cerebellum is involved in cognitive processing and emotion control. Cerebellar alterations could explain symptoms of schizophrenia spectrum disorder (SZ) and bipolar disorder (BD). In addition, literature suggests that lithium might influence cerebellar anatomy. Our aim was to study cerebellar anatomy in SZ and BD, and investigate the effect of lithium. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
To examine the long‐term (up to 10 years) patterns related to cannabis use in a sample of patients with first episode of psychosis (FEP) and the effect that consumption might have on clinical, functioning, and neurocognition at long‐term.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
Contrary to the assertion of Paris, diverse indicators suggest that the diagnosis and treatment of dissociative identity disorder (DID) are resurgent rather than retreating. This commentary reviews the evidence that justifies the description of this condition as controversial, including research into dissociative amnesia. The potential harm that can result from a diagnosis of DID and risky treatment techniques, including hypnosis and abreaction, are described. It is suggested that this scientifically unproven and potentially harmful treatment model should be confronted and quelled and its diagnosis and treatment subjected to critical clinical review, including randomised controlled trials, as a matter of urgency. A plea is made for the Royal College of Psychiatrists to update its 1997 guidance document and for professional training to incorporate updated psychological and neurobiological research on human memory.. To read the full article, log in using your MPFT NHS OpenAthens details.
Psychosis is a complex presentation with a wide range of factors contributing to its development, biological and environmental. Psychosis is a feature present in a variety of psychiatric disorders. It is important for clinicians to keep up to date with evidence regarding current understanding of the reasons psychosis may occur. Furthermore, it is necessary to find clinical utility from this knowledge so that effective primary, secondary and tertiary preventative strategies can be considered. This article is the first of a three-part series that examines contemporary knowledge of risk factors for psychosis and presents an overview of current explanations. The articles focus on the psychosis risk timeline, which gives a structure within which to consider key aspects of risk likely to affect people at different stages of life. In this first article, early life is discussed. It covers elements that contribute in the prenatal and early childhood period and includes genetic, nutritional and infective risk factors.. To read the full article, log in using your MPFT NHS OpenAthens details.
To explore the temporal dynamic of antidepressant and antipsychotic co‐prescribing in real‐life conditions.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
To quantify the risk of hip fracture, thromboembolism, stroke, myocardial infarction,pneumonia, and sudden cardiac death associated with exposure to antipsychotics.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
It is salutary to recall that schizophrenia was generally regarded as a functional psychosis, rather than an organic psychosis like dementia, at that time, about 30 years ago. One implication of this diagnostic dogma was that the brain was not expected to look structurally (organically) abnormal in schizophrenia. The first CT studies generated intense controversy by providing disruptive evidence for significant enlargement of the ventricles (1). It is a measure of the theoretical impact of neuroimaging in psychiatry that the prior concept of functional psychosis has been largely abandoned in the face of overwhelming evidence of structural brain imaging abnormalities in schizophrenia. It is now beyond reasonable doubt that the brain does not look structurally normal in schizophrenia, but it remains an open question how best to characterize and interpret the abnormalities disclosed by contemporary MRI research. Login at top right hand side of page using your MPFT NHS OpenAthens for full text.
The Altman Self‐Rating Mania Scale (ASRM) was originally published in 1997 as a self‐rated measure aimed at assessing the severity of manic symptoms [1]. The published ASRM consists of the following five symptom items: i) elevated mood, ii) Increased self‐esteem, iii) decreased need for sleep, iv) pressured speech, and v) psychomotor agitation, which are rated by the patients via endorsement of one of five statements ranging from 0 (symptom not present) to 4 (symptom present in severe degree) [1].. To read the full article, log in using your MPFT NHS OpenAthens details.
Digital health interventions present an important opportunity to improve health care for people with psychosis or bipolar disorder, but despite their potential, integrating and implementing them into clinical settings has been difficult worldwide. This Review aims to identify factors affecting implementation of digital health interventions for people affected by psychosis or bipolar disorder.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai