Individualized metacognitive training (MCT+) is a novel psychotherapy that has been designed to specifically target delusional beliefs in people with psychosis. It works by developing an awareness of the implausible content of delusional beliefs, while also targeting the cognitive biases that contribute to their formation and maintenance. It was expected that MCT+ would lead to significantly greater reductions in delusional severity compared to a cognitive remediation (CR) active control condition. . Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
People with schizophrenia experience significant deficits in the kinds of empathic skills that are the foundation for interpersonal relationships. Researchers have speculated that deficits in empathic skills in schizophrenia may be related to disturbances in metacognition and heightened levels of personal distress. To explore this issue, this study examined whether better metacognition and reduced personal distress would be associated with improved performance on cognitive and affective empathy tasks.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Psychological Medicine; Cambridge Vol. 49, Iss. 1, (Jan 2019): 140-148. DOI:10.1017/S0033291718000600
Schizophrenia and autism spectrum disorder (ASD) are currently conceptualized as distinct disorders. However, the relationship between these two disorders has been revisited in recent years due to evidence that they share phenotypic and genotypic expressions. This study aimed to identify ASD traits in patients with schizophrenia, and to define their demographic, psychopathological, cognitive and functional correlates.. To read the full article, log in using your NHS OpenAthens details.
The Altman Self‐Rating Mania Scale (ASRM) was originally published in 1997 as a self‐rated measure aimed at assessing the severity of manic symptoms [1]. The published ASRM consists of the following five symptom items: i) elevated mood, ii) Increased self‐esteem, iii) decreased need for sleep, iv) pressured speech, and v) psychomotor agitation, which are rated by the patients via endorsement of one of five statements ranging from 0 (symptom not present) to 4 (symptom present in severe degree) [1].. To read the full article, log in using your MPFT NHS OpenAthens details.
Social and occupational impairments contribute to the burden of psychosis and depression. There is a need for risk stratification tools to inform personalized functional-disability preventive strategies for individuals in at-risk and early phases of these illnesses.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Digital health interventions present an important opportunity to improve health care for people with psychosis or bipolar disorder, but despite their potential, integrating and implementing them into clinical settings has been difficult worldwide. This Review aims to identify factors affecting implementation of digital health interventions for people affected by psychosis or bipolar disorder.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Comment. Many smokers and health-care providers believe that smoking can reduce stress and other symptoms related to poor mental health. In The Lancet Psychiatry, Jentien Vermeulen and colleagues 1 examined the self-medication hypothesis in a prospective cohort study of patients with a non-affective psychosis (n=1094), unaffected siblings (n=1047), and control participants (n=579).. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Psychotic symptoms may occur in any dementia, including Alzheimer’s disease (AD), but are particularly common in Lewy body dementia (LBD). The mechanisms of psychotic symptoms are largely unknown. Psychosis has been found to be associated with more severe AD and Lewy body pathology in patients with AD and cerebrovascular disease-related vasculopathy.1 One form of vascular pathology, cerebral amylod angiopathy (CAA), is defined as deposits of amyloid in the vessel walls that increase risk of haemorrhage and ischaemia. CAA contributes to neurodegeneration, but its relation to clinical symptoms and course in dementia is not fully understood.2. To read the full article, log in using your NHS OpenAthens details.
Cortical thickness reductions in schizophrenia are irregularly distributed across multiple loci. The authors hypothesized that cortical connectivity networks would explain the distribution of cortical thickness reductions across the cortex, and, specifically, that cortico-cortical connectivity between loci with these reductions would be exceptionally strong and form an interconnected network. This hypothesis was tested in three cross-sectional schizophrenia cohorts: first-episode psychosis, chronic schizophrenia, and treatment-resistant schizophrenia.. Login at top right hand side of page using your MPFT NHS OpenAthens for full text.
To quantify the risk of hip fracture, thromboembolism, stroke, myocardial infarction,pneumonia, and sudden cardiac death associated with exposure to antipsychotics.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
It is salutary to recall that schizophrenia was generally regarded as a functional psychosis, rather than an organic psychosis like dementia, at that time, about 30 years ago. One implication of this diagnostic dogma was that the brain was not expected to look structurally (organically) abnormal in schizophrenia. The first CT studies generated intense controversy by providing disruptive evidence for significant enlargement of the ventricles (1). It is a measure of the theoretical impact of neuroimaging in psychiatry that the prior concept of functional psychosis has been largely abandoned in the face of overwhelming evidence of structural brain imaging abnormalities in schizophrenia. It is now beyond reasonable doubt that the brain does not look structurally normal in schizophrenia, but it remains an open question how best to characterize and interpret the abnormalities disclosed by contemporary MRI research. Login at top right hand side of page using your MPFT NHS OpenAthens for full text.
Commentary. People with severe mental illness have higher mortality rates, culminating in about 20 years of lost life compared with that of the general population, and momentum is growing to reduce this inequality.1, 2 In the general population, neighbourhood social context is related to mortality, but whether such patterns also exist for people with severe mental illness has received little attention. Understanding this relationship could allow us to tailor social interventions for this distinctive population. The study by Jayati Das-Munshi and colleagues3 in The Lancet Psychiatry represents a welcome step in that direction, linking higher neighbourhood ethnic density to lower mortality rates among people with severe mental illness from ethnic minority backgrounds. These results raise the intriguing possibility that factors associated with ethnic density might promote longevity among people with severe mental illness.. Please contact the library to request a copy of this article - http://bit.ly/2HjNDf3
To explore the temporal dynamic of antidepressant and antipsychotic co‐prescribing in real‐life conditions.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
This research suggests that contrary to popular opinion delaying exposure to cannabis does not appear to reduce the chances of using more of the drug as an older teenager. However, it does suggest that there does not appear to be a strong relationship between developing psychosis as a trigger to stop using cannabis. Again, this won’t come as a surprise to those working with this age group in the mental health or drug field as they will have witnessed this with the young people they encounter as part of their work.
Clozapine is the only antipsychotic that is effective in treatment-resistant schizophrenia. However, in certain clinical situations, such as the emergence of serious adverse effects, it is necessary to discontinue clozapine. Stopping clozapine treatment poses a particular challenge due to the risk of psychotic relapse, as well as the development of withdrawal symptoms. Despite these challenges for the clinician, there is currently no formal guidance on how to safely to discontinue clozapine. We assessed the feasibility of developing evidence-based recommendations for (1) minimizing the risk of withdrawal symptoms, (2) managing withdrawal phenomena, and (3) commencing alternatives treatment when clozapine is discontinued. To read the full article, log in using your MPFT NHS OpenAthens details.
Cognitive impairment in schizophrenia predicts functional outcomes and is largely unresponsive to pharmacology or psychotherapy; it is thus a critical unmet treatment need. This article presents the impact of remotely completed, intensive, targeted auditory training (AT) vs control condition computer games (CG) in a double-blind randomized trial in young adults with recent-onset schizophrenia. To read the full article, log in using your MPFT NHS OpenAthens details.
Indicated prevention in young people at Clinical High Risk for Psychosis (CHR-P) originated in Australia more than 20 years ago1 and subsequently impacted national and international clinical guidelines2 and diagnostic manuals.3 While the most recent umbrella reviews (reviews of meta-analyses) demonstrated substantial achievements in detection and prognostic assessment of young CHR-P individuals,4 the most updated network meta-analysis found no robust evidence to favor cognitive behavioral therapy (CBT) compared with the control condition (ie, needs-based interventions) To read the full article, log in using your MPFT NHS OpenAthens details.