Abstract
Hydrangenone, a new heptacyclic isoprenoid with a 6/7/6/5/5 membered
carbon ring skeleton, was Isolated from the aerial parts of Salvia
hydrangea. The structure was established by extensive NMR spectroscopic
methods. The relative and absolute configuration of 1 was assigned by
NOESY and X-ray crystallographic analysis and by comparison of
experimental and calculated electronic circular dichroism (ECD) spectra.
Compound 1 showed in vitro antiplasmodial activity, with an IC50 value
of 1.4 mu M against P. falciparum. A plausible biosynthetic pathway of 1
was also proposed.
Users
Please
log in to take part in the discussion (add own reviews or comments).