%0 Journal Article %1 Garten:2009:Science:19465683 %A Garten, R J %A Davis, C T %A Russell, C A %A Shu, B %A Lindstrom, S %A Balish, A %A Sessions, W M %A Xu, X %A Skepner, E %A Deyde, V %A Okomo-Adhiambo, M %A Gubareva, L %A Barnes, J %A Smith, C B %A Emery, S L %A Hillman, M J %A Rivailler, P %A Smagala, J %A de Graaf, M %A Burke, D F %A Fouchier, R A %A Pappas, C %A Alpuche-Aranda, C M %A López-Gatell, H %A Olivera, H %A López, I %A Myers, C A %A Faix, D %A Blair, P J %A Yu, C %A Keene, K M %A Dotson, P D %A Boxrud, D %A Sambol, A R %A Abid, S H %A George, K St %A Bannerman, T %A Moore, A L %A Stringer, D J %A Blevins, P %A Demmler-Harrison, G J %A Ginsberg, M %A Kriner, P %A Waterman, S %A Smole, S %A Guevara, H F %A Belongia, E A %A Clark, P A %A Beatrice, S T %A Donis, R %A Katz, J %A Finelli, L %A Bridges, C B %A Shaw, M %A Jernigan, D B %A Uyeki, T M %A Smith, D J %A Klimov, A I %A Cox, N J %D 2009 %J Science %K epi evolution flu imported %N 5937 %P 197-201 %R 10.1126/science.1176225 %T Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans %U http://www.ncbi.nlm.nih.gov/pubmed/19465683?dopt=Abstract %V 325 %X Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The lack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period. Its low genetic diversity suggests that the introduction into humans was a single event or multiple events of similar viruses. Molecular markers predictive of adaptation to humans are not currently present in 2009 A(H1N1) viruses, suggesting that previously unrecognized molecular determinants could be responsible for the transmission among humans. Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1).

@article{Garten:2009:Science:19465683, abstract = {Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The lack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period. Its low genetic diversity suggests that the introduction into humans was a single event or multiple events of similar viruses. Molecular markers predictive of adaptation to humans are not currently present in 2009 A(H1N1) viruses, suggesting that previously unrecognized molecular determinants could be responsible for the transmission among humans. Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1).}, added-at = {2009-07-31T23:47:32.000+0200}, author = {Garten, R J and Davis, C T and Russell, C A and Shu, B and Lindstrom, S and Balish, A and Sessions, W M and Xu, X and Skepner, E and Deyde, V and Okomo-Adhiambo, M and Gubareva, L and Barnes, J and Smith, C B and Emery, S L and Hillman, M J and Rivailler, P and Smagala, J and de Graaf, M and Burke, D F and Fouchier, R A and Pappas, C and Alpuche-Aranda, C M and L{\'o}pez-Gatell, H and Olivera, H and L{\'o}pez, I and Myers, C A and Faix, D and Blair, P J and Yu, C and Keene, K M and Dotson, P D and Boxrud, D and Sambol, A R and Abid, S H and George, K St and Bannerman, T and Moore, A L and Stringer, D J and Blevins, P and Demmler-Harrison, G J and Ginsberg, M and Kriner, P and Waterman, S and Smole, S and Guevara, H F and Belongia, E A and Clark, P A and Beatrice, S T and Donis, R and Katz, J and Finelli, L and Bridges, C B and Shaw, M and Jernigan, D B and Uyeki, T M and Smith, D J and Klimov, A I and Cox, N J}, biburl = {https://www.bibsonomy.org/bibtex/2c482df70b9ec5d6ddebc15c77a55c702/ebo}, description = {Antigenic and genetic characteristics of swine-ori...[Science. 2009] - PubMed Result}, doi = {10.1126/science.1176225}, interhash = {14c800d0cc950d33b7a0d6790366b562}, intrahash = {c482df70b9ec5d6ddebc15c77a55c702}, journal = {Science}, keywords = {epi evolution flu imported}, month = Jul, number = 5937, pages = {197-201}, pmid = {19465683}, timestamp = {2009-07-31T23:47:32.000+0200}, title = {Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans}, url = {http://www.ncbi.nlm.nih.gov/pubmed/19465683?dopt=Abstract}, volume = 325, year = 2009 }