Аннотация
Existing models describing the kinetics of receptor-effector interaction
were found to be insufficient to account for the experimental findings
on adenylate cyclase activation by A2 adenosine receptors described
in the preceding manuscript Mol. Pharmacol. 39: 517-523 (1991).
We have, therefore, chosen another approach and have developed discrete
computer simulations of receptor-effector interactions taking place
on a spherical membrane. These simulations were based on the following
principles: (a) receptors activate effectors in a catalytic manner,
and (b) diffusion of receptors and effectors is slow, so that receptors
will only activate effectors that are in their vicinity at the time
of agonist occupation. Using several experimentally determined parameters,
these simulations could reproduce the experimental findings on adenylate
cyclase activation by A2 adenosine receptors described in the preceding
manuscript. In addition, by appropriate choice of the simulation
parameters, they are shown to accommodate the behavior of several
other models of receptor-effector interactions.
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