%0 Journal Article %1 springerlink:10.1007/s00018-010-0352-4 %A Frank, Martin %A Schloissnig, Siegfried %D 2010 %I Birkhäuser Basel %J Cellular and Molecular Life Sciences %K bioinformatics glycobiology modeling molecular nmr %N 16 %P 2749-2772 %R 10.1007/s00018-010-0352-4 %T Bioinformatics and molecular modeling in glycobiology %U http://dx.doi.org/10.1007/s00018-010-0352-4 %V 67 %X The field of glycobiology is concerned with the study of the structure, properties, and biological functions of the family of biomolecules called carbohydrates. Bioinformatics for glycobiology is a particularly challenging field, because carbohydrates exhibit a high structural diversity and their chains are often branched. Significant improvements in experimental analytical methods over recent years have led to a tremendous increase in the amount of carbohydrate structure data generated. Consequently, the availability of databases and tools to store, retrieve and analyze these data in an efficient way is of fundamental importance to progress in glycobiology. In this review, the various graphical representations and sequence formats of carbohydrates are introduced, and an overview of newly developed databases, the latest developments in sequence alignment and data mining, and tools to support experimental glycan analysis are presented. Finally, the field of structural glycoinformatics and molecular modeling of carbohydrates, glycoproteins, and protein–carbohydrate interaction are reviewed.

@article{springerlink:10.1007/s00018-010-0352-4, abstract = {The field of glycobiology is concerned with the study of the structure, properties, and biological functions of the family of biomolecules called carbohydrates. Bioinformatics for glycobiology is a particularly challenging field, because carbohydrates exhibit a high structural diversity and their chains are often branched. Significant improvements in experimental analytical methods over recent years have led to a tremendous increase in the amount of carbohydrate structure data generated. Consequently, the availability of databases and tools to store, retrieve and analyze these data in an efficient way is of fundamental importance to progress in glycobiology. In this review, the various graphical representations and sequence formats of carbohydrates are introduced, and an overview of newly developed databases, the latest developments in sequence alignment and data mining, and tools to support experimental glycan analysis are presented. Finally, the field of structural glycoinformatics and molecular modeling of carbohydrates, glycoproteins, and protein–carbohydrate interaction are reviewed.}, added-at = {2012-08-05T11:41:12.000+0200}, affiliation = {Deutsches Krebsforschungszentrum (German Cancer Research Centre) Molecular Structure Analysis Core Facility-W160 Im Neuenheimer Feld 280 69120 Heidelberg Germany}, author = {Frank, Martin and Schloissnig, Siegfried}, biburl = {https://www.bibsonomy.org/bibtex/230e91012cbafb8b29cbde52989c0955a/rstenutz}, description = {Cellular and Molecular Life Sciences, Volume 67, Number 16 - SpringerLink}, doi = {10.1007/s00018-010-0352-4}, interhash = {d0df61c0d61ea7f13370850b2087c42f}, intrahash = {30e91012cbafb8b29cbde52989c0955a}, issn = {1420-682X}, journal = {Cellular and Molecular Life Sciences}, keyword = {Biomedical and Life Sciences}, keywords = {bioinformatics glycobiology modeling molecular nmr}, number = 16, pages = {2749-2772}, publisher = {Birkhäuser Basel}, timestamp = {2012-08-05T11:41:12.000+0200}, title = {Bioinformatics and molecular modeling in glycobiology}, url = {http://dx.doi.org/10.1007/s00018-010-0352-4}, volume = 67, year = 2010 }