Abstract
Ethyl diazoacetate is an important organic chemistry synthon, but
its use as an industrial intermediate is limited due in part to the
safety concerns associated with its instability and high reactivity.
Reported are the reaction calorimetry results obtained from a new
ethyl diazoacetate preparative method, the results from its use in
a novel, exothermic reaction and the application of this data toward
process development, a successful pilot plant campaign and full-scale
reactor design. The results indicate that, given the proper engineering
design, in situ preparation and use of ethyl diazoacetate solutions
can be used at production scale without significant risk.
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