The risk factors for acquisition of secondary day-care-associated Haemophilus influenzae type b disease were evaluated in a cohort of children in Seattle-King County, Washington; Atlanta; and the state of Oklahoma. During the study period, 129 primary cases were identified in children less than 5 years old who attended day-care facilities. In ten instances (8\%), a secondary case occurred between one and 60 days after a primary case in the same classroom. Risk of secondary disease in classroom contacts was strongly age related: 2.4\% in children 0 to 11 months old, 1.2\% in children 12 to 23 months old, and 0.0\% in children 24 to 59 months old. Controlling for age, children attending day-care more hours per week were more likely to transmit or acquire secondary disease. Risk of secondary disease for children in other classrooms at a center where a case had occurred was not significantly greater than risk of primary disease. Administration of rifampin to classroom contacts of a child with invasive H influenzae was effective in preventing secondary cases (95\% confidence interval for rifampin efficacy, 47\% to 100\%). For children 0 to 23 months old not treated with rifampin, risk of secondary disease was 2.7\% (95\% confidence interval, 1.1\% to 4.3\%), a risk approaching that reported in household contacts.
%0 Journal Article
%1 fleming_secondary_1985
%A Fleming, D W
%A Leibenhaut, M H
%A Albanes, D
%A Cochi, S L
%A Hightower, A W
%A Makintubee, S
%A Helgerson, S D
%A Broome, C V
%D 1985
%J JAMA: The Journal of the American Medical Association
%K Age Bacterial Care Centers, Child Child, Day Factors, Georgia, Haemophilus Haemophilus, Humans, Infant, Infections, Membrane Meningitis, Newborn, Oklahoma, Outer Preschool, Proteins, Rifampin, Risk, Time Washington influenzae,
%N 4
%P 509--14
%T Secondary Haemophilus influenzae type b in day-care facilities. Risk factors and prevention
%U http://www.ncbi.nlm.nih.gov/pubmed/3874293
%V 254
%X The risk factors for acquisition of secondary day-care-associated Haemophilus influenzae type b disease were evaluated in a cohort of children in Seattle-King County, Washington; Atlanta; and the state of Oklahoma. During the study period, 129 primary cases were identified in children less than 5 years old who attended day-care facilities. In ten instances (8\%), a secondary case occurred between one and 60 days after a primary case in the same classroom. Risk of secondary disease in classroom contacts was strongly age related: 2.4\% in children 0 to 11 months old, 1.2\% in children 12 to 23 months old, and 0.0\% in children 24 to 59 months old. Controlling for age, children attending day-care more hours per week were more likely to transmit or acquire secondary disease. Risk of secondary disease for children in other classrooms at a center where a case had occurred was not significantly greater than risk of primary disease. Administration of rifampin to classroom contacts of a child with invasive H influenzae was effective in preventing secondary cases (95\% confidence interval for rifampin efficacy, 47\% to 100\%). For children 0 to 23 months old not treated with rifampin, risk of secondary disease was 2.7\% (95\% confidence interval, 1.1\% to 4.3\%), a risk approaching that reported in household contacts.
@article{fleming_secondary_1985,
abstract = {The risk factors for acquisition of secondary day-care-associated Haemophilus influenzae type b disease were evaluated in a cohort of children in {Seattle-King} County, Washington; Atlanta; and the state of Oklahoma. During the study period, 129 primary cases were identified in children less than 5 years old who attended day-care facilities. In ten instances (8\%), a secondary case occurred between one and 60 days after a primary case in the same classroom. Risk of secondary disease in classroom contacts was strongly age related: 2.4\% in children 0 to 11 months old, 1.2\% in children 12 to 23 months old, and 0.0\% in children 24 to 59 months old. Controlling for age, children attending day-care more hours per week were more likely to transmit or acquire secondary disease. Risk of secondary disease for children in other classrooms at a center where a case had occurred was not significantly greater than risk of primary disease. Administration of rifampin to classroom contacts of a child with invasive H influenzae was effective in preventing secondary cases (95\% confidence interval for rifampin efficacy, 47\% to 100\%). For children 0 to 23 months old not treated with rifampin, risk of secondary disease was 2.7\% (95\% confidence interval, 1.1\% to 4.3\%), a risk approaching that reported in household contacts.},
added-at = {2011-03-11T10:05:34.000+0100},
author = {Fleming, D W and Leibenhaut, M H and Albanes, D and Cochi, S L and Hightower, A W and Makintubee, S and Helgerson, S D and Broome, C V},
biburl = {https://www.bibsonomy.org/bibtex/2423756f25660ac6d9fd885dea974e1c3/jelias},
interhash = {d3ea0229bba68e64fb5032cb8dc8898a},
intrahash = {423756f25660ac6d9fd885dea974e1c3},
issn = {0098-7484},
journal = {{JAMA:} The Journal of the American Medical Association},
keywords = {Age Bacterial Care Centers, Child Child, Day Factors, Georgia, Haemophilus Haemophilus, Humans, Infant, Infections, Membrane Meningitis, Newborn, Oklahoma, Outer Preschool, Proteins, Rifampin, Risk, Time Washington influenzae,},
month = jul,
note = {{PMID:} 3874293},
number = 4,
pages = {509--14},
timestamp = {2011-03-11T10:06:48.000+0100},
title = {Secondary Haemophilus influenzae type b in day-care facilities. Risk factors and prevention},
url = {http://www.ncbi.nlm.nih.gov/pubmed/3874293},
volume = 254,
year = 1985
}