%0 Journal Article %1 barbour_impact_1995 %A Barbour, M L %A Mayon-White, R T %A Coles, C %A Crook, D W %A Moxon, E R %D 1995 %J The Journal of Infectious Diseases %K Bacterial Capsules, Carrier Cohort Conjugate Family Family, Female, Haemophilus Health, Humans, Infant, Infections, Male, Mothers, Nuclear Pharynx, Questionnaires, State, Studies, Tetanus Toxoid, Vaccination, Vaccines, influenzae, {Case-Control} %N 1 %P 93--8 %T The impact of conjugate vaccine on carriage of Haemophilus influenzae type b %U http://www.ncbi.nlm.nih.gov/pubmed/7798687 %V 171 %X Conjugate vaccines against Haemophilus influenzae type b (Hib) may modify Hib pharyngeal colonization. Hib colonization was compared in 371 infants and their families. In Oxfordshire, infants received PRP-T (polyribosylribitol phosphate conjugated to tetanus toxoid) and in Buckinghamshire they did not (controls). Infants were followed at 6, 9, and 12 months of age. Also, 6 unvaccinated Hib carriers were vaccinated and followed for 6 weeks. Hib acquisition was lower in vaccinees than controls (P \textless .01). During surveillance, 1.5\% of vaccinees and 6.3\% of controls carried Hib (P = .04). Among those with family Hib exposure, the carriage rates were 8.7\% and 38.5\% (P = .07), respectively. Hiv carriage rates were lower among vaccinees' unvaccinated siblings. Giving conjugate vaccine to a child carrying Hib did not rapidly terminate carriage. Thus, a primary means by which herd immunity to Hib is induced in a vaccinated population may be through reduction or delay in the initial acquisition of Hib.

@article{barbour_impact_1995, abstract = {Conjugate vaccines against Haemophilus influenzae type b {(Hib)} may modify Hib pharyngeal colonization. Hib colonization was compared in 371 infants and their families. In Oxfordshire, infants received {PRP-T} (polyribosylribitol phosphate conjugated to tetanus toxoid) and in Buckinghamshire they did not (controls). Infants were followed at 6, 9, and 12 months of age. Also, 6 unvaccinated Hib carriers were vaccinated and followed for 6 weeks. Hib acquisition was lower in vaccinees than controls {(P} {\textless} .01). During surveillance, 1.5\% of vaccinees and 6.3\% of controls carried Hib {(P} = .04). Among those with family Hib exposure, the carriage rates were 8.7\% and 38.5\% {(P} = .07), respectively. Hiv carriage rates were lower among vaccinees' unvaccinated siblings. Giving conjugate vaccine to a child carrying Hib did not rapidly terminate carriage. Thus, a primary means by which herd immunity to Hib is induced in a vaccinated population may be through reduction or delay in the initial acquisition of Hib.}, added-at = {2011-03-11T10:05:34.000+0100}, author = {Barbour, M L and {Mayon-White}, R T and Coles, C and Crook, D W and Moxon, E R}, biburl = {https://www.bibsonomy.org/bibtex/248702cabb7524885e84e289abbd16ac9/jelias}, interhash = {b29d6037aeb0e463df54bba47fb221b6}, intrahash = {48702cabb7524885e84e289abbd16ac9}, issn = {0022-1899}, journal = {The Journal of Infectious Diseases}, keywords = {Bacterial Capsules, Carrier Cohort Conjugate Family Family, Female, Haemophilus Health, Humans, Infant, Infections, Male, Mothers, Nuclear Pharynx, Questionnaires, State, Studies, Tetanus Toxoid, Vaccination, Vaccines, influenzae, {Case-Control}}, month = jan, note = {{PMID:} 7798687}, number = 1, pages = {93--8}, timestamp = {2011-03-11T10:06:04.000+0100}, title = {The impact of conjugate vaccine on carriage of Haemophilus influenzae type b}, url = {http://www.ncbi.nlm.nih.gov/pubmed/7798687}, volume = 171, year = 1995 }