The principal Epstein-Barr virus (EBV) oncoprotein, Latent Membrane Protein 1 (LMP1), is expressed in most EBV-associated human malignancies. LMP1 mimics CD40 receptor signaling to provide infected cells with constitutive NF-κB, MAP kinase, IRF7, and PI3 kinase pathway stimulation. EBV-transformed B-cells are particularly dependent on constitutive NF-κB activity, and rapidly undergo apoptosis upon NF-κB blockade. Here, we review LMP1 function, with special attention to current understanding of the molecular mechanisms of LMP1-mediated NF-κB and IRF7 pathway activation. Recent advances include the elucidation of transmembrane motifs important for LMP1 trafficking and ligand-independent signaling, analysis of genome-wide LMP1 gene targets, and the identification of novel cell proteins that mediate LMP1 NF-κB and IRF7 pathway activation.
%0 Journal Article
%1 v5061587
%A Ersing, Ina
%A Bernhardt, Katharina
%A Gewurz, Benjamin E.
%D 2013
%J Viruses
%K myown
%N 6
%P 1587
%R 10.3390/v5061587
%T NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1
%U http://www.mdpi.com/1999-4915/5/6/1587
%V 5
%X The principal Epstein-Barr virus (EBV) oncoprotein, Latent Membrane Protein 1 (LMP1), is expressed in most EBV-associated human malignancies. LMP1 mimics CD40 receptor signaling to provide infected cells with constitutive NF-κB, MAP kinase, IRF7, and PI3 kinase pathway stimulation. EBV-transformed B-cells are particularly dependent on constitutive NF-κB activity, and rapidly undergo apoptosis upon NF-κB blockade. Here, we review LMP1 function, with special attention to current understanding of the molecular mechanisms of LMP1-mediated NF-κB and IRF7 pathway activation. Recent advances include the elucidation of transmembrane motifs important for LMP1 trafficking and ligand-independent signaling, analysis of genome-wide LMP1 gene targets, and the identification of novel cell proteins that mediate LMP1 NF-κB and IRF7 pathway activation.
@article{v5061587,
abstract = {The principal Epstein-Barr virus (EBV) oncoprotein, Latent Membrane Protein 1 (LMP1), is expressed in most EBV-associated human malignancies. LMP1 mimics CD40 receptor signaling to provide infected cells with constitutive NF-κB, MAP kinase, IRF7, and PI3 kinase pathway stimulation. EBV-transformed B-cells are particularly dependent on constitutive NF-κB activity, and rapidly undergo apoptosis upon NF-κB blockade. Here, we review LMP1 function, with special attention to current understanding of the molecular mechanisms of LMP1-mediated NF-κB and IRF7 pathway activation. Recent advances include the elucidation of transmembrane motifs important for LMP1 trafficking and ligand-independent signaling, analysis of genome-wide LMP1 gene targets, and the identification of novel cell proteins that mediate LMP1 NF-κB and IRF7 pathway activation.},
added-at = {2016-11-19T02:52:16.000+0100},
author = {Ersing, Ina and Bernhardt, Katharina and Gewurz, Benjamin E.},
biburl = {https://www.bibsonomy.org/bibtex/24d8430d61aeb07b9be86c3949fc5ccfc/bgewurz},
doi = {10.3390/v5061587},
interhash = {51ff8f9a296fa72db1e158902ebdd7fe},
intrahash = {4d8430d61aeb07b9be86c3949fc5ccfc},
issn = {1999-4915},
journal = {Viruses},
keywords = {myown},
number = 6,
pages = 1587,
pubmedid = {23793113},
timestamp = {2016-11-19T02:52:16.000+0100},
title = {NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1},
url = {http://www.mdpi.com/1999-4915/5/6/1587},
volume = 5,
year = 2013
}