OBJECTIVE: The prime intent of this study was to determine the relationship if any between the last fetal biophysical profile score and the risk of cerebral palsy at age 3 years. The secondary objective was to examine the clinical characteristics of infants with cerebral palsy whose obstetric management included serial fetal biophysical profile scores. STUDY DESIGN: The incidence of a high risk pregnant population whose antenatal assessment was by serial fetal biophysical profile scoring was determined by cross-referencing two discrete data bases. The completeness and reliability of the data bases was confirmed by secondary audit. Obstetrical, neonatal and post-natal clinical records of index cases of cerebral palsy were subsequently reviewed, categorized and analyzed. RESULTS: Fetal biophysical profile scores (BPS) were recorded in 22,336 high risk pregnancies: 27 patients delivered an infant subsequently identified as having cerebral palsy (rate 1.21 per 1000). The relationship between last BPS result and cerebral palsy was inverse, exponential and highly significant (R2 = 0.987; p < 0.001). Affected infants with a last abnormal BPS result were significantly more likely to exhibit fetal distress (88.8\%), acidosis (77.7\%), and have neonatal seizures (88.8\%). Antenatal asphyxia was the apparent cause of cerebral damage in 29.6\% of cases. CONCLUSION: The last fetal biophysical profile score is a predictor of the risk of cerebral palsy.
%0 Journal Article
%1 Manning1997
%A Manning, F. A.
%A Bondagji, N.
%A Harman, C. R.
%A Casiro, O.
%A Menticoglou, S.
%A Morrison, I.
%D 1997
%J J Gynecol Obstet Biol Reprod (Paris)
%K Cerebral Palsy; Female; Fetal Monitoring; Humans; Infant, Newborn; Manitoba; Medical Audit; Predictive Value of Tests; Pregnancy; Pregnancy Outcome; Pregnancy, High-Risk; Reproducibility Results; Risk Factors
%N 7
%P 720--729
%T Fetal assessment based on the fetal biophysical profile score: relationship of last BPS result to subsequent cerebral palsy.
%V 26
%X OBJECTIVE: The prime intent of this study was to determine the relationship if any between the last fetal biophysical profile score and the risk of cerebral palsy at age 3 years. The secondary objective was to examine the clinical characteristics of infants with cerebral palsy whose obstetric management included serial fetal biophysical profile scores. STUDY DESIGN: The incidence of a high risk pregnant population whose antenatal assessment was by serial fetal biophysical profile scoring was determined by cross-referencing two discrete data bases. The completeness and reliability of the data bases was confirmed by secondary audit. Obstetrical, neonatal and post-natal clinical records of index cases of cerebral palsy were subsequently reviewed, categorized and analyzed. RESULTS: Fetal biophysical profile scores (BPS) were recorded in 22,336 high risk pregnancies: 27 patients delivered an infant subsequently identified as having cerebral palsy (rate 1.21 per 1000). The relationship between last BPS result and cerebral palsy was inverse, exponential and highly significant (R2 = 0.987; p < 0.001). Affected infants with a last abnormal BPS result were significantly more likely to exhibit fetal distress (88.8\%), acidosis (77.7\%), and have neonatal seizures (88.8\%). Antenatal asphyxia was the apparent cause of cerebral damage in 29.6\% of cases. CONCLUSION: The last fetal biophysical profile score is a predictor of the risk of cerebral palsy.
@article{Manning1997,
abstract = {OBJECTIVE: The prime intent of this study was to determine the relationship if any between the last fetal biophysical profile score and the risk of cerebral palsy at age 3 years. The secondary objective was to examine the clinical characteristics of infants with cerebral palsy whose obstetric management included serial fetal biophysical profile scores. STUDY DESIGN: The incidence of a high risk pregnant population whose antenatal assessment was by serial fetal biophysical profile scoring was determined by cross-referencing two discrete data bases. The completeness and reliability of the data bases was confirmed by secondary audit. Obstetrical, neonatal and post-natal clinical records of index cases of cerebral palsy were subsequently reviewed, categorized and analyzed. RESULTS: Fetal biophysical profile scores (BPS) were recorded in 22,336 high risk pregnancies: 27 patients delivered an infant subsequently identified as having cerebral palsy (rate 1.21 per 1000). The relationship between last BPS result and cerebral palsy was inverse, exponential and highly significant (R2 = 0.987; p < 0.001). Affected infants with a last abnormal BPS result were significantly more likely to exhibit fetal distress (88.8\%), acidosis (77.7\%), and have neonatal seizures (88.8\%). Antenatal asphyxia was the apparent cause of cerebral damage in 29.6\% of cases. CONCLUSION: The last fetal biophysical profile score is a predictor of the risk of cerebral palsy.},
added-at = {2014-07-19T20:45:25.000+0200},
author = {Manning, F. A. and Bondagji, N. and Harman, C. R. and Casiro, O. and Menticoglou, S. and Morrison, I.},
biburl = {https://www.bibsonomy.org/bibtex/2518c56d734e15c6864426efed7f2d0ad/ar0berts},
groups = {public},
interhash = {574396eb996567ef99e711a0b64559cc},
intrahash = {518c56d734e15c6864426efed7f2d0ad},
journal = {J Gynecol Obstet Biol Reprod (Paris)},
keywords = {Cerebral Palsy; Female; Fetal Monitoring; Humans; Infant, Newborn; Manitoba; Medical Audit; Predictive Value of Tests; Pregnancy; Pregnancy Outcome; Pregnancy, High-Risk; Reproducibility Results; Risk Factors},
number = 7,
pages = {720--729},
pii = {66999},
pmid = {9436057},
timestamp = {2014-07-19T20:45:25.000+0200},
title = {Fetal assessment based on the fetal biophysical profile score: relationship of last BPS result to subsequent cerebral palsy.},
username = {ar0berts},
volume = 26,
year = 1997
}