International Union of Basic and Clinical Pharmacology. LXVII. Recommendations
for the recognition and nomenclature of G protein-coupled receptor
heteromultimers
J. Pin, R. Neubig, M. Bouvier, L. Devi, M. Filizola, J. Javitch, M. Lohse, G. Milligan, K. Palczewski, M. Parmentier, and M. Spedding. Pharmacol Rev, 59 (1):
5-13(March 2007)Pin, Jean-Philippe Neubig, Richard Bouvier, Michel Devi, Lakshmi
Filizola, Marta Javitch, Jonathan A Lohse, Martin J Milligan, Graeme
Palczewski, Krzysztof Parmentier, Marc Spedding, Michael Review United
States Pharmacological reviews Pharmacol Rev. 2007 Mar;59(1):5-13..
Abstract
G protein-coupled receptors (GPCRs) have long been considered to be
monomeric membrane proteins. Although numerous recent studies have
indicated that GPCRs can form multimeric complexes, the functional
and pharmacological consequences of this phenomenon have remained
elusive. With the discovery that the functional GABA(B) receptor
is an obligate heterodimer and with the use of energy transfer technologies,
it is now accepted that GPCRs can form heteromultimers. In some cases,
specific properties of such heteromers not shared by their respective
homomers have been reported. Although in most cases these properties
have only been observed in heterologous expression systems, there
are a few reports describing data consistent with such heteromultimeric
GPCR complexes also existing in native tissues. The present article
illustrates well-documented examples of such native multimeric complexes,
lists a number of recommendations for recognition and acceptance
of such multimeric receptors, and gives recommendations for their
nomenclature.
International Union of Basic and Clinical Pharmacology. LXVII. Recommendations
for the recognition and nomenclature of G protein-coupled receptor
heteromultimers
Pin, Jean-Philippe Neubig, Richard Bouvier, Michel Devi, Lakshmi
Filizola, Marta Javitch, Jonathan A Lohse, Martin J Milligan, Graeme
Palczewski, Krzysztof Parmentier, Marc Spedding, Michael Review United
States Pharmacological reviews Pharmacol Rev. 2007 Mar;59(1):5-13.
%0 Journal Article
%1 Pin2007
%A Pin, J. P.
%A Neubig, R.
%A Bouvier, M.
%A Devi, L.
%A Filizola, M.
%A Javitch, J. A.
%A Lohse, M. J.
%A Milligan, G.
%A Palczewski, K.
%A Parmentier, M.
%A Spedding, M.
%D 2007
%J Pharmacol Rev
%K & *Guidelines *Terminology Agencies Animals Clinical/methods/organization Dimerization G-Protein-Coupled/chemistry/*classification/metabolism Humans International Pharmacology, Topic administration as Receptor
%N 1
%P 5-13
%T International Union of Basic and Clinical Pharmacology. LXVII. Recommendations
for the recognition and nomenclature of G protein-coupled receptor
heteromultimers
%U http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17329545
%V 59
%X G protein-coupled receptors (GPCRs) have long been considered to be
monomeric membrane proteins. Although numerous recent studies have
indicated that GPCRs can form multimeric complexes, the functional
and pharmacological consequences of this phenomenon have remained
elusive. With the discovery that the functional GABA(B) receptor
is an obligate heterodimer and with the use of energy transfer technologies,
it is now accepted that GPCRs can form heteromultimers. In some cases,
specific properties of such heteromers not shared by their respective
homomers have been reported. Although in most cases these properties
have only been observed in heterologous expression systems, there
are a few reports describing data consistent with such heteromultimeric
GPCR complexes also existing in native tissues. The present article
illustrates well-documented examples of such native multimeric complexes,
lists a number of recommendations for recognition and acceptance
of such multimeric receptors, and gives recommendations for their
nomenclature.
@article{Pin2007,
abstract = {G protein-coupled receptors (GPCRs) have long been considered to be
monomeric membrane proteins. Although numerous recent studies have
indicated that GPCRs can form multimeric complexes, the functional
and pharmacological consequences of this phenomenon have remained
elusive. With the discovery that the functional GABA(B) receptor
is an obligate heterodimer and with the use of energy transfer technologies,
it is now accepted that GPCRs can form heteromultimers. In some cases,
specific properties of such heteromers not shared by their respective
homomers have been reported. Although in most cases these properties
have only been observed in heterologous expression systems, there
are a few reports describing data consistent with such heteromultimeric
GPCR complexes also existing in native tissues. The present article
illustrates well-documented examples of such native multimeric complexes,
lists a number of recommendations for recognition and acceptance
of such multimeric receptors, and gives recommendations for their
nomenclature.},
added-at = {2010-12-14T18:12:02.000+0100},
author = {Pin, J. P. and Neubig, R. and Bouvier, M. and Devi, L. and Filizola, M. and Javitch, J. A. and Lohse, M. J. and Milligan, G. and Palczewski, K. and Parmentier, M. and Spedding, M.},
biburl = {https://www.bibsonomy.org/bibtex/25f13962a1bb7c7eafeecd9249249b42e/pharmawuerz},
endnotereftype = {Journal Article},
interhash = {c30357e6896d71854eeb9d4192868935},
intrahash = {5f13962a1bb7c7eafeecd9249249b42e},
issn = {0031-6997 (Print) 0031-6997 (Linking)},
journal = {Pharmacol Rev},
keywords = {& *Guidelines *Terminology Agencies Animals Clinical/methods/organization Dimerization G-Protein-Coupled/chemistry/*classification/metabolism Humans International Pharmacology, Topic administration as Receptor},
month = Mar,
note = {Pin, Jean-Philippe Neubig, Richard Bouvier, Michel Devi, Lakshmi
Filizola, Marta Javitch, Jonathan A Lohse, Martin J Milligan, Graeme
Palczewski, Krzysztof Parmentier, Marc Spedding, Michael Review United
States Pharmacological reviews Pharmacol Rev. 2007 Mar;59(1):5-13.},
number = 1,
pages = {5-13},
shorttitle = {International Union of Basic and Clinical Pharmacology. LXVII. Recommendations
for the recognition and nomenclature of G protein-coupled receptor
heteromultimers},
timestamp = {2010-12-14T18:20:08.000+0100},
title = {International Union of Basic and Clinical Pharmacology. LXVII. Recommendations
for the recognition and nomenclature of G protein-coupled receptor
heteromultimers},
url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17329545},
volume = 59,
year = 2007
}