%0 Journal Article %1 WOS:000326194600008 %A Silva, Acarilia Eduardo %A Oliveira, Elquio Eleamen %A Gomes, Monique C Salgado %A Marcelino, Henrique Rodrigues %A Silva, Karen C Holanda %A Souza, Bartolomeu Santos %A Nagashima-Jr., Toshiyuki %A Ayala, Alejandro Pedro %A Oliveira, Anselmo Gomes %A do Egito, Eryvaldo Socrates Tabosa %C 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND %D 2013 %I TAYLOR & FRANCIS LTD %J JOURNAL OF MICROENCAPSULATION %K analysis} infrared interaction; polymer-biopolymer spectroscopy; spray-drying; thermal {Cross-linking; %N 8 %P 787-795 %R 10.3109/02652048.2013.788087 %T Producing xylan/Eudragit (R) S100-based microparticles by chemical and physico-mechanical approaches as carriers for 5-aminosalicylic acid %V 30 %X Xylan is a biopolymer found in a variety of cell wall plants. Eudragit (R) S-100 (ES100), a pH-dependent polymer, is used as a coating material in gastroresistant delivery systems. In this study, microparticles based on both polymers were produced by interfacial cross-linking polymerisation and/or spray-drying technique in order to investigate feasibility and stability of the systems. Size and morphology of the microparticles were characterised by optical and SEM while FT-IR, thermal analysis (TG/DTA), and X-ray diffraction (XRD) evaluated the drug-polymer interactions and the thermal behaviour of the systems. FT-IR confirmed the absence of chemical interaction between the polymers. TG/DTA analysis showed a higher stability for spray-dried microparticles and XRD data proved the amorphous feature of both carriers. The results reveal that xylan/ES100 microparticles can be produced by chemical or physico-mechanical ways, the latter being the best option due to the lack of toxic cross-linking agents and easy scale-up.

@article{WOS:000326194600008, abstract = {Xylan is a biopolymer found in a variety of cell wall plants. Eudragit (R) S-100 (ES100), a pH-dependent polymer, is used as a coating material in gastroresistant delivery systems. In this study, microparticles based on both polymers were produced by interfacial cross-linking polymerisation and/or spray-drying technique in order to investigate feasibility and stability of the systems. Size and morphology of the microparticles were characterised by optical and SEM while FT-IR, thermal analysis (TG/DTA), and X-ray diffraction (XRD) evaluated the drug-polymer interactions and the thermal behaviour of the systems. FT-IR confirmed the absence of chemical interaction between the polymers. TG/DTA analysis showed a higher stability for spray-dried microparticles and XRD data proved the amorphous feature of both carriers. The results reveal that xylan/ES100 microparticles can be produced by chemical or physico-mechanical ways, the latter being the best option due to the lack of toxic cross-linking agents and easy scale-up.}, added-at = {2022-05-23T20:00:14.000+0200}, address = {2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND}, author = {Silva, Acarilia Eduardo and Oliveira, Elquio Eleamen and Gomes, Monique C Salgado and Marcelino, Henrique Rodrigues and Silva, Karen C Holanda and Souza, Bartolomeu Santos and Nagashima-Jr., Toshiyuki and Ayala, Alejandro Pedro and Oliveira, Anselmo Gomes and do Egito, Eryvaldo Socrates Tabosa}, biburl = {https://www.bibsonomy.org/bibtex/261c0d2d8e6fc5dfa30c45800b503a0e1/ppgfis_ufc_br}, doi = {10.3109/02652048.2013.788087}, interhash = {e6871f2f525fa87a73a33f888b9e0fd7}, intrahash = {61c0d2d8e6fc5dfa30c45800b503a0e1}, issn = {0265-2048}, journal = {JOURNAL OF MICROENCAPSULATION}, keywords = {analysis} infrared interaction; polymer-biopolymer spectroscopy; spray-drying; thermal {Cross-linking;}, number = 8, pages = {787-795}, publisher = {TAYLOR & FRANCIS LTD}, pubstate = {published}, timestamp = {2022-05-23T20:00:14.000+0200}, title = {Producing xylan/Eudragit (R) S100-based microparticles by chemical and physico-mechanical approaches as carriers for 5-aminosalicylic acid}, tppubtype = {article}, volume = 30, year = 2013 }