%0 Journal Article %1 grundl2020interaction %A Gründl, Marco %A Walz, Susanne %A Hauf, Laura %A Schwab, Melissa %A Werner, Kerstin Marcela %A Spahr, Susanne %A Schulte, Clemens %A Maric, Hans Michael %A Ade, Carsten P. %A Gaubatz, Stefan %D 2020 %I Public Library of Science %J PLOS Genetics %K maric %N 5 %P e1008818-- %T Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes %U https://doi.org/10.1371/journal.pgen.1008818 %V 16 %X Author summary YAP, the major downstream transducer of the Hippo pathway, is a potent inducer of proliferation. Here we show that the Myb-MuvB complex (MMB) mediates cardiomyocyte proliferation by YAP. We find that YAP and MMB regulate an overlapping set of pro-proliferative genes which involves binding of MMB to the promoters of these genes. We also identified a direct interaction between the B-MYB subunit of MMB and YAP. Based on the binding studies, we created a tool called MY-COMP that interferes with the association YAP to B-MYB and strongly inhibits proliferation of cardiomyocytes. Together, our data suggests that the YAP-MMB interaction is essential for division of cardiomyocytes, underscoring the functional relevance of the crosstalk between these two pathways for proper heart development.

@article{grundl2020interaction, abstract = {Author summary YAP, the major downstream transducer of the Hippo pathway, is a potent inducer of proliferation. Here we show that the Myb-MuvB complex (MMB) mediates cardiomyocyte proliferation by YAP. We find that YAP and MMB regulate an overlapping set of pro-proliferative genes which involves binding of MMB to the promoters of these genes. We also identified a direct interaction between the B-MYB subunit of MMB and YAP. Based on the binding studies, we created a tool called MY-COMP that interferes with the association YAP to B-MYB and strongly inhibits proliferation of cardiomyocytes. Together, our data suggests that the YAP-MMB interaction is essential for division of cardiomyocytes, underscoring the functional relevance of the crosstalk between these two pathways for proper heart development.}, added-at = {2021-04-07T09:20:29.000+0200}, author = {Gründl, Marco and Walz, Susanne and Hauf, Laura and Schwab, Melissa and Werner, Kerstin Marcela and Spahr, Susanne and Schulte, Clemens and Maric, Hans Michael and Ade, Carsten P. and Gaubatz, Stefan}, biburl = {https://www.bibsonomy.org/bibtex/2a02bbe8730c4fab67a36729723cb5d9f/reichert}, interhash = {f8f8ba102d82c8ee59b45047b437bbfc}, intrahash = {a02bbe8730c4fab67a36729723cb5d9f}, journal = {PLOS Genetics}, keywords = {maric}, month = may, number = 5, pages = {e1008818--}, publisher = {Public Library of Science}, timestamp = {2021-04-07T09:20:29.000+0200}, title = {Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes}, url = {https://doi.org/10.1371/journal.pgen.1008818}, volume = 16, year = 2020 }