Summary
The spread of meticillin-resistant Staphylococcus aureus (MRSA) is a major problem for both acute care hospitals and among residents in long term care facilities (LTCFs). We performed a cohort study to assess the natural history of MRSA colonisation in LTCF residents. Two cohorts of residents (231 MRSA carriers and 196 non-carriers) were followed up for an 18 month period, with cultures of nasal and decubitus ulcers performed every six months. In the MRSA carrier cohort, 110 (47.8\%) residents had persistent MRSA colonisation for six months or longer, 44 (19.0\%) had transient colonisation and nine (3.9\%) were intermittently colonised. No risk factors for persistent MRSA colonisation could be determined. The annual incidence of MRSA acquisition was around 20\% 95\% confidence interval (CI): 14.3-25.5. Antibiotic treatment was independently associated with MRSA acquisition (odds ratio: 2.27; 95\% CI: 1.05-4.88; P = 0.03). Just two clones were distinguishable by pulsed-field gel electrophoresis and multilocus sequence typing: CC5-MRSA IV, which is widely disseminated in Spanish hospitals, and ST22-MRSA IV. This study adds to the knowledge of the epidemiology of MRSA in community LTCFs, which are important components of long term care in Spain.
%0 Journal Article
%1 manzur_natural_2010
%A Manzur, A.
%A Dominguez, M.A.
%A de Gopegui, E. Ruiz
%A Mariscal, D.
%A Gavalda, L.
%A Segura, F.
%A Perez, J.L.
%A Pujol, M.
%D 2010
%J Journal of Hospital Infection
%K Epidemiology, Geriatrics, Long Meticillin-resistant Staphylococcus aureus care, term
%N 3
%P 215--219
%R 10.1016/j.jhin.2010.05.022
%T Natural history of meticillin-resistant Staphylococcus aureus colonisation among residents in community long term care facilities in Spain
%U http://www.sciencedirect.com/science/article/B6WJP-50RFMN0-3/2/40df0ecac708dfea35202bb79aad7a52
%V 76
%X Summary
The spread of meticillin-resistant Staphylococcus aureus (MRSA) is a major problem for both acute care hospitals and among residents in long term care facilities (LTCFs). We performed a cohort study to assess the natural history of MRSA colonisation in LTCF residents. Two cohorts of residents (231 MRSA carriers and 196 non-carriers) were followed up for an 18 month period, with cultures of nasal and decubitus ulcers performed every six months. In the MRSA carrier cohort, 110 (47.8\%) residents had persistent MRSA colonisation for six months or longer, 44 (19.0\%) had transient colonisation and nine (3.9\%) were intermittently colonised. No risk factors for persistent MRSA colonisation could be determined. The annual incidence of MRSA acquisition was around 20\% 95\% confidence interval (CI): 14.3-25.5. Antibiotic treatment was independently associated with MRSA acquisition (odds ratio: 2.27; 95\% CI: 1.05-4.88; P = 0.03). Just two clones were distinguishable by pulsed-field gel electrophoresis and multilocus sequence typing: CC5-MRSA IV, which is widely disseminated in Spanish hospitals, and ST22-MRSA IV. This study adds to the knowledge of the epidemiology of MRSA in community LTCFs, which are important components of long term care in Spain.
@article{manzur_natural_2010,
abstract = {Summary
The spread of meticillin-resistant Staphylococcus aureus {(MRSA)} is a major problem for both acute care hospitals and among residents in long term care facilities {(LTCFs).} We performed a cohort study to assess the natural history of {MRSA} colonisation in {LTCF} residents. Two cohorts of residents (231 {MRSA} carriers and 196 non-carriers) were followed up for an 18 month period, with cultures of nasal and decubitus ulcers performed every six months. In the {MRSA} carrier cohort, 110 (47.8\%) residents had persistent {MRSA} colonisation for six months or longer, 44 (19.0\%) had transient colonisation and nine (3.9\%) were intermittently colonised. No risk factors for persistent {MRSA} colonisation could be determined. The annual incidence of {MRSA} acquisition was around 20\% [95\% confidence interval {(CI):} 14.3-25.5]. Antibiotic treatment was independently associated with {MRSA} acquisition (odds ratio: 2.27; 95\% {CI:} 1.05-4.88; P = 0.03). Just two clones were distinguishable by pulsed-field gel electrophoresis and multilocus sequence typing: {CC5-MRSA} {IV,} which is widely disseminated in Spanish hospitals, and {ST22-MRSA} {IV.} This study adds to the knowledge of the epidemiology of {MRSA} in community {LTCFs,} which are important components of long term care in Spain.},
added-at = {2011-03-11T10:05:34.000+0100},
author = {Manzur, A. and Dominguez, {M.A.} and de Gopegui, E. Ruiz and Mariscal, D. and Gavalda, L. and Segura, F. and Perez, {J.L.} and Pujol, M.},
biburl = {https://www.bibsonomy.org/bibtex/2aee01d52a4c4f3a8fd59bf0434856fa1/jelias},
doi = {10.1016/j.jhin.2010.05.022},
interhash = {5a39fcf649c5ae17e244fd65d1150f41},
intrahash = {aee01d52a4c4f3a8fd59bf0434856fa1},
issn = {0195-6701},
journal = {Journal of Hospital Infection},
keywords = {Epidemiology, Geriatrics, Long Meticillin-resistant Staphylococcus aureus care, term},
month = nov,
number = 3,
pages = {215--219},
timestamp = {2011-03-11T10:05:50.000+0100},
title = {Natural history of meticillin-resistant Staphylococcus aureus colonisation among residents in community long term care facilities in Spain},
url = {http://www.sciencedirect.com/science/article/B6WJP-50RFMN0-3/2/40df0ecac708dfea35202bb79aad7a52},
volume = 76,
year = 2010
}