Unless selection is very intense, the number of deaths needed to secure the substitution, by natural selection, of one gene for another at a locus, is independent of the intensity of selection. It is often about 30 times the number of organisms in a generation. It is suggested that, in horotelic evolution, the mean time taken for each gene substitution is . about 300 generations. This accords with the observed slowness of evolution.
%0 Journal Article
%1 haldane1957natural
%A Haldane, J. B. S.
%D 1957
%J Journal of Genetics
%K cost_of_selection cost_of_substitution genetic_load population_genetics selective_sweep
%N 3
%P 511
%R 10.1007/BF02984069
%T The cost of natural selection
%U https://doi.org/10.1007/BF02984069
%V 55
%X Unless selection is very intense, the number of deaths needed to secure the substitution, by natural selection, of one gene for another at a locus, is independent of the intensity of selection. It is often about 30 times the number of organisms in a generation. It is suggested that, in horotelic evolution, the mean time taken for each gene substitution is . about 300 generations. This accords with the observed slowness of evolution.
@article{haldane1957natural,
abstract = {Unless selection is very intense, the number of deaths needed to secure the substitution, by natural selection, of one gene for another at a locus, is independent of the intensity of selection. It is often about 30 times the number of organisms in a generation. It is suggested that, in horotelic evolution, the mean time taken for each gene substitution is . about 300 generations. This accords with the observed slowness of evolution.},
added-at = {2018-04-06T21:54:03.000+0200},
author = {Haldane, J. B. S.},
biburl = {https://www.bibsonomy.org/bibtex/2c6d7fd3e50119e29ed6b9d4f1736fd75/peter.ralph},
day = 01,
doi = {10.1007/BF02984069},
interhash = {22017a5e735731bc0916c3a27d85763a},
intrahash = {c6d7fd3e50119e29ed6b9d4f1736fd75},
issn = {0022-1333},
journal = {Journal of Genetics},
keywords = {cost_of_selection cost_of_substitution genetic_load population_genetics selective_sweep},
month = dec,
number = 3,
pages = 511,
timestamp = {2020-06-26T06:51:44.000+0200},
title = {The cost of natural selection},
url = {https://doi.org/10.1007/BF02984069},
volume = 55,
year = 1957
}