Fc receptors are key players of the immune system that link the fine specificity of immunoglobulins and innate effector responses. Here, we describe a nonmammalian Fcgamma receptor, CHIR-AB1, a member of the leukocyte receptor complex, that binds IgY with high affinity with its single Ig domain. It is expressed on immature and mature B lymphocytes, monocytes, macrophages, and natural killer cells and harbors motifs of activating and inhibitory Fc receptors. In the absence of FcepsilonRIgamma, CHIR-AB1 can be expressed on B cells but cross-linking does not induce intracellular calcium release. In contrast, cells expressing CHIR-AB1 and FcepsilonRIgamma are triggered to release intracellular calcium upon stimulation with heat-aggregated IgY. CHIR-AB1 thus represents a primordial Fc receptor that combines features of different mammalian counterparts.
Description
The chicken leukocyte receptor complex encodes a p... [Proc Natl Acad Sci U S A. 2007] - PubMed result
%0 Journal Article
%1 Viertlboeck:2007:Proc-Natl-Acad-Sci-U-S-A:17606923
%A Viertlboeck, B. C.
%A Schweinsberg, S.
%A Hanczaruk, M. A.
%A Schmitt, R.
%A Pasquier, L. Du
%A Herberg, F. W.
%A Göbel, T. W.
%D 2007
%J Proc Natl Acad Sci U S A
%K herberg myown
%N 28
%P 11718-11723
%R 10.1073/pnas.0702011104
%T The chicken leukocyte receptor complex encodes a primordial, activating, high-affinity IgY Fc receptor
%U http://www.ncbi.nlm.nih.gov/pubmed/17606923
%V 104
%X Fc receptors are key players of the immune system that link the fine specificity of immunoglobulins and innate effector responses. Here, we describe a nonmammalian Fcgamma receptor, CHIR-AB1, a member of the leukocyte receptor complex, that binds IgY with high affinity with its single Ig domain. It is expressed on immature and mature B lymphocytes, monocytes, macrophages, and natural killer cells and harbors motifs of activating and inhibitory Fc receptors. In the absence of FcepsilonRIgamma, CHIR-AB1 can be expressed on B cells but cross-linking does not induce intracellular calcium release. In contrast, cells expressing CHIR-AB1 and FcepsilonRIgamma are triggered to release intracellular calcium upon stimulation with heat-aggregated IgY. CHIR-AB1 thus represents a primordial Fc receptor that combines features of different mammalian counterparts.
@article{Viertlboeck:2007:Proc-Natl-Acad-Sci-U-S-A:17606923,
abstract = {Fc receptors are key players of the immune system that link the fine specificity of immunoglobulins and innate effector responses. Here, we describe a nonmammalian Fcgamma receptor, CHIR-AB1, a member of the leukocyte receptor complex, that binds IgY with high affinity with its single Ig domain. It is expressed on immature and mature B lymphocytes, monocytes, macrophages, and natural killer cells and harbors motifs of activating and inhibitory Fc receptors. In the absence of FcepsilonRIgamma, CHIR-AB1 can be expressed on B cells but cross-linking does not induce intracellular calcium release. In contrast, cells expressing CHIR-AB1 and FcepsilonRIgamma are triggered to release intracellular calcium upon stimulation with heat-aggregated IgY. CHIR-AB1 thus represents a primordial Fc receptor that combines features of different mammalian counterparts.},
added-at = {2010-10-14T10:11:02.000+0200},
author = {Viertlboeck, B. C. and Schweinsberg, S. and Hanczaruk, M. A. and Schmitt, R. and Pasquier, L. Du and Herberg, F. W. and G{\"o}bel, T. W.},
biburl = {https://www.bibsonomy.org/bibtex/2d36b4d02a1f523f6b91fa2b6aa729a39/biochemie},
description = {The chicken leukocyte receptor complex encodes a p... [Proc Natl Acad Sci U S A. 2007] - PubMed result},
doi = {10.1073/pnas.0702011104},
interhash = {b94515833ae812aa771881ec607c1e0c},
intrahash = {d36b4d02a1f523f6b91fa2b6aa729a39},
journal = {Proc Natl Acad Sci U S A},
keywords = {herberg myown},
month = jul,
number = 28,
pages = {11718-11723},
pmid = {17606923},
timestamp = {2012-07-24T09:38:41.000+0200},
title = {The chicken leukocyte receptor complex encodes a primordial, activating, high-affinity IgY Fc receptor},
url = {http://www.ncbi.nlm.nih.gov/pubmed/17606923},
volume = 104,
year = 2007
}