The ryanodine receptors (RyRs) are a family of Ca$^2+$ release
channels found on intracellular Ca$^2+$ storage/release organelles.
The RyR channels are ubiquitously expressed in many types of cells
and participate in a variety of important Ca$^2+$ signaling phenomena
(neurotransmission, secretion, etc.). In striated muscle, the RyR
channels represent the primary pathway for Ca$^2+$ release during
the excitation-contraction coupling process. In general, the signals
that activate the RyR channels are known (e.g., sarcolemmal Ca$^2+$
influx or depolarization), but the specific mechanisms involved are
still being debated. The signals that modulate and/or turn off the
RyR channels remain ambiguous and the mechanisms involved unclear.
Over the last decade, studies of RyR-mediated Ca$^2+$ release
have taken many forms and have steadily advanced our knowledge. This
robust field, however, is not without controversial ideas and contradictory
results. Controversies surrounding the complex Ca$^2+$ regulation
of single RyR channels receive particular attention here. In addition,
a large body of information is synthesized into a focused perspective
of single RyR channel function. The present status of the single
RyR channel field and its likely future directions are also discussed.
%0 Journal Article
%1 Fill_2002_893
%A Fill, Michael
%A Copello, Julio A
%D 2002
%J Physiol. Rev.
%K 12270947 Adaptation, Animals, Calcium Calcium, Channel, Channels, Feedback, Gov't, Humans, Non-U.S. P.H.S., Physiological, Receptor Release Research Ryanodine Ryanodine, Signaling, Support, U.S.
%N 4
%P 893--922
%R 10.1152/physrev.00013.2002
%T Ryanodine receptor calcium release channels.
%U http://dx.doi.org/10.1152/physrev.00013.2002
%V 82
%X The ryanodine receptors (RyRs) are a family of Ca$^2+$ release
channels found on intracellular Ca$^2+$ storage/release organelles.
The RyR channels are ubiquitously expressed in many types of cells
and participate in a variety of important Ca$^2+$ signaling phenomena
(neurotransmission, secretion, etc.). In striated muscle, the RyR
channels represent the primary pathway for Ca$^2+$ release during
the excitation-contraction coupling process. In general, the signals
that activate the RyR channels are known (e.g., sarcolemmal Ca$^2+$
influx or depolarization), but the specific mechanisms involved are
still being debated. The signals that modulate and/or turn off the
RyR channels remain ambiguous and the mechanisms involved unclear.
Over the last decade, studies of RyR-mediated Ca$^2+$ release
have taken many forms and have steadily advanced our knowledge. This
robust field, however, is not without controversial ideas and contradictory
results. Controversies surrounding the complex Ca$^2+$ regulation
of single RyR channels receive particular attention here. In addition,
a large body of information is synthesized into a focused perspective
of single RyR channel function. The present status of the single
RyR channel field and its likely future directions are also discussed.
@article{Fill_2002_893,
abstract = {The ryanodine receptors (RyRs) are a family of {C}a$^{2+}$ release
channels found on intracellular {C}a$^{2+}$ storage/release organelles.
The RyR channels are ubiquitously expressed in many types of cells
and participate in a variety of important {C}a$^{2+}$ signaling phenomena
(neurotransmission, secretion, etc.). In striated muscle, the RyR
channels represent the primary pathway for {C}a$^{2+}$ release during
the excitation-contraction coupling process. In general, the signals
that activate the RyR channels are known (e.g., sarcolemmal {C}a$^{2+}$
influx or depolarization), but the specific mechanisms involved are
still being debated. The signals that modulate and/or turn off the
RyR channels remain ambiguous and the mechanisms involved unclear.
Over the last decade, studies of RyR-mediated {C}a$^{2+}$ release
have taken many forms and have steadily advanced our knowledge. This
robust field, however, is not without controversial ideas and contradictory
results. Controversies surrounding the complex {C}a$^{2+}$ regulation
of single RyR channels receive particular attention here. In addition,
a large body of information is synthesized into a focused perspective
of single RyR channel function. The present status of the single
RyR channel field and its likely future directions are also discussed.},
added-at = {2009-06-03T11:20:58.000+0200},
author = {Fill, Michael and Copello, Julio A},
biburl = {https://www.bibsonomy.org/bibtex/2d3c1b7ded515fb40f3623fdf3b6243b3/hake},
description = {The whole bibliography file I use.},
doi = {10.1152/physrev.00013.2002},
file = {Fill_2002_893.pdf:Fill_2002_893.pdf:PDF},
interhash = {9b20166ff6c230db61fad6ce9a462af0},
intrahash = {d3c1b7ded515fb40f3623fdf3b6243b3},
journal = {Physiol. Rev.},
key = 125,
keywords = {12270947 Adaptation, Animals, Calcium Calcium, Channel, Channels, Feedback, Gov't, Humans, Non-U.S. P.H.S., Physiological, Receptor Release Research Ryanodine Ryanodine, Signaling, Support, U.S.},
month = Oct,
number = 4,
pages = {893--922},
pmid = {12270947},
timestamp = {2009-06-03T11:21:11.000+0200},
title = {Ryanodine receptor calcium release channels.},
url = {http://dx.doi.org/10.1152/physrev.00013.2002},
volume = 82,
year = 2002
}