PURPOSE OF REVIEW: To describe the impact of highly active antiretroviral therapy on the burden of pneumococcal disease and advances in our understanding of the impact of HIV on this disease. RECENT FINDINGS: Although highly active antiretroviral therapy has reduced the burden of pneumococcal disease among HIV-infected adults, these infections remain far more common than in HIV uninfected adults. HIV-infected adults who smoke or have comorbidities are at particular risk. In the absence of highly active antiretroviral therapy, pneumococcal meningitis has emerged in Africa as a major disease burden with a high mortality among HIV-infected children and adults. Conjugate pneumococcal vaccine protects HIV-infected infants from pneumococcal pneumonia. In the United States, where conjugate vaccine is given to children, herd immunity has reduced the burden of invasive pneumococcal disease among HIV-infected adults. SUMMARY: The pneumococcus remains a significant cause of morbidity and mortality among HIV-infected children and adults, both in developed and in developing countries.
%0 Journal Article
%1 klugman_hiv_2007
%A Klugman, Keith P
%A Madhi, Shabir A
%A Feldman, Charles
%D 2007
%J Current Opinion in Infectious Diseases
%K Agents, Conjugate Cost Humans, Illness, Infections, Pneumococcal Streptococcus Vaccines, of pneumoniae, {Anti-Retroviral} {HIV}
%N 1
%P 11--5
%R 10.1097/QCO.0b013e328012c5f1
%T HIV and pneumococcal disease
%U http://www.ncbi.nlm.nih.gov/pubmed/17197876
%V 20
%X PURPOSE OF REVIEW: To describe the impact of highly active antiretroviral therapy on the burden of pneumococcal disease and advances in our understanding of the impact of HIV on this disease. RECENT FINDINGS: Although highly active antiretroviral therapy has reduced the burden of pneumococcal disease among HIV-infected adults, these infections remain far more common than in HIV uninfected adults. HIV-infected adults who smoke or have comorbidities are at particular risk. In the absence of highly active antiretroviral therapy, pneumococcal meningitis has emerged in Africa as a major disease burden with a high mortality among HIV-infected children and adults. Conjugate pneumococcal vaccine protects HIV-infected infants from pneumococcal pneumonia. In the United States, where conjugate vaccine is given to children, herd immunity has reduced the burden of invasive pneumococcal disease among HIV-infected adults. SUMMARY: The pneumococcus remains a significant cause of morbidity and mortality among HIV-infected children and adults, both in developed and in developing countries.
@article{klugman_hiv_2007,
abstract = {{PURPOSE} {OF} {REVIEW:} To describe the impact of highly active antiretroviral therapy on the burden of pneumococcal disease and advances in our understanding of the impact of {HIV} on this disease. {RECENT} {FINDINGS:} Although highly active antiretroviral therapy has reduced the burden of pneumococcal disease among {HIV-infected} adults, these infections remain far more common than in {HIV} uninfected adults. {HIV-infected} adults who smoke or have comorbidities are at particular risk. In the absence of highly active antiretroviral therapy, pneumococcal meningitis has emerged in Africa as a major disease burden with a high mortality among {HIV-infected} children and adults. Conjugate pneumococcal vaccine protects {HIV-infected} infants from pneumococcal pneumonia. In the United States, where conjugate vaccine is given to children, herd immunity has reduced the burden of invasive pneumococcal disease among {HIV-infected} adults. {SUMMARY:} The pneumococcus remains a significant cause of morbidity and mortality among {HIV-infected} children and adults, both in developed and in developing countries.},
added-at = {2011-03-11T10:05:34.000+0100},
author = {Klugman, Keith P and Madhi, Shabir A and Feldman, Charles},
biburl = {https://www.bibsonomy.org/bibtex/2da77b1c9675997eb6bf2e025f51f632f/jelias},
doi = {10.1097/QCO.0b013e328012c5f1},
interhash = {b010b3ddfa73ef65819c2e5c37fc01b2},
intrahash = {da77b1c9675997eb6bf2e025f51f632f},
issn = {0951-7375},
journal = {Current Opinion in Infectious Diseases},
keywords = {Agents, Conjugate Cost Humans, Illness, Infections, Pneumococcal Streptococcus Vaccines, of pneumoniae, {Anti-Retroviral} {HIV}},
month = feb,
note = {{PMID:} 17197876},
number = 1,
pages = {11--5},
timestamp = {2011-03-11T10:06:47.000+0100},
title = {{HIV} and pneumococcal disease},
url = {http://www.ncbi.nlm.nih.gov/pubmed/17197876},
volume = 20,
year = 2007
}