Until recently, it was impracticable to identify the genes that are responsible for variation in continuous traits, or to directly observe the effects of their different alleles. Now, the abundance of genetic markers has made it possible to identify quantitative trait loci (QTL)--the regions of a chromosome or, ideally, individual sequence variants that are responsible for trait variation. What kind of QTL do we expect to find and what can our observations of QTL tell us about how organisms evolve? The key to understanding the evolutionary significance of QTL is to understand the nature of inherited variation, not in the immediate mechanistic sense of how genes influence phenotype, but, rather, to know what evolutionary forces maintain genetic variability.
%0 Journal Article
%1 barton2002understanding
%A Barton, N H
%A Keightley, P D
%D 2002
%J Nat Rev Genet
%K QTL infinitesimal_model polygenic_adaptation quantitative_genetics review selection
%N 1
%P 11-21
%R 10.1038/nrg700
%T Understanding quantitative genetic variation
%U http://www.ncbi.nlm.nih.gov/pubmed/11823787
%V 3
%X Until recently, it was impracticable to identify the genes that are responsible for variation in continuous traits, or to directly observe the effects of their different alleles. Now, the abundance of genetic markers has made it possible to identify quantitative trait loci (QTL)--the regions of a chromosome or, ideally, individual sequence variants that are responsible for trait variation. What kind of QTL do we expect to find and what can our observations of QTL tell us about how organisms evolve? The key to understanding the evolutionary significance of QTL is to understand the nature of inherited variation, not in the immediate mechanistic sense of how genes influence phenotype, but, rather, to know what evolutionary forces maintain genetic variability.
@article{barton2002understanding,
abstract = {Until recently, it was impracticable to identify the genes that are responsible for variation in continuous traits, or to directly observe the effects of their different alleles. Now, the abundance of genetic markers has made it possible to identify quantitative trait loci (QTL)--the regions of a chromosome or, ideally, individual sequence variants that are responsible for trait variation. What kind of QTL do we expect to find and what can our observations of QTL tell us about how organisms evolve? The key to understanding the evolutionary significance of QTL is to understand the nature of inherited variation, not in the immediate mechanistic sense of how genes influence phenotype, but, rather, to know what evolutionary forces maintain genetic variability.},
added-at = {2015-05-02T07:37:51.000+0200},
author = {Barton, N H and Keightley, P D},
biburl = {https://www.bibsonomy.org/bibtex/2ecb41965567694691f826640cd82d459/peter.ralph},
doi = {10.1038/nrg700},
interhash = {8cc2a7904a69867d366202b78177c064},
intrahash = {ecb41965567694691f826640cd82d459},
journal = {Nat Rev Genet},
keywords = {QTL infinitesimal_model polygenic_adaptation quantitative_genetics review selection},
month = jan,
number = 1,
pages = {11-21},
pmid = {11823787},
timestamp = {2015-05-02T07:37:51.000+0200},
title = {Understanding quantitative genetic variation},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11823787},
volume = 3,
year = 2002
}