Abstract
Three new 3-hydroxy-N-methyl-2-oxindole (1 and 2) and
4-hydroxy-pyran-2-one (3) derivatives, along with the known
3-hydroxy-N-methyl-2-oxindole (4) and 6-methoxy-N-methylisatin (5) were
isolated from a marine Salinispora arenicola strain from sediments of
the St. Peter and St. Paul Archipelago, Brazil. The structures of the
new compounds were elucidated by a combination of spectroscopic (1D and
2D NMR and HR-ESIMS) data, including single-crystal X-ray diffraction
analysis for 2 and 3. Compounds 1 to 5 were assayed for their
antimicrobial properties, but only 4 and 5 were active against
Enterococcus faecalis with MIC value of 15.6 mu g/mL.
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