Abstract
The discovery of mutations in cancer genes has advanced our understanding
of cancer. These results are dispersed across the scientific literature
and with the availability of the human genome sequence will continue
to accrue. The COSMIC (Catalogue of Somatic Mutations in Cancer)
database and website have been developed to store somatic mutation
data in a single location and display the data and other information
related to human cancer. To populate this resource, data has currently
been extracted from reports in the scientific literature for somatic
mutations in four genes, BRAF, HRAS, KRAS2 and NRAS. At present,
the database holds information on 66 634 samples and reports a total
of 10 647 mutations. Through the web pages, these data can be queried,
displayed as figures or tables and exported in a number of formats.
COSMIC is an ongoing project that will continue to curate somatic
mutation data and release it through the website.
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