%0 Journal Article %1 Nix.2006 %A Nix, %A Erstad, B. L. %A Nakazato, P. Z. %A Barletta, J. F. %A Matthias, K. R. %A Krueger, T. S. %D 2006 %J ANNALS OF PHARMACOTHERAPY %K CIRRHOSIS CREATININE GLOMERULAR-FILTRATION-RATE MARKERS PREDICTABILITY PREDICTION RENAL-FUNCTION SERUM SURVIVAL TRANSPLANTATION assay clearance creatinine disease function liver renal %N 5 %P 900-908 %T Estimation of creatinine clearance in end-stage liver disease %V 40 %X BACKGROUND: Estimation of renal function in patients with end-stage liver disease (ESLD) is complicated by several factors. OBJECTIVE: To develop a practical and relatively inexpensive method for estimating creatinine production and clearance in patients with ESLD. METHODS: Serum creatinine concentrations and urinary excretion of creatinine were measured in 27 patients with moderate-to-severe liver disease with the goal of developing equations to predict creatinine clearance from serum creatinine. Subjects were studied during an initial evaluation for a liver transplant program. Two 24 hour urine specimens were collected along with 3 serum samples over a 2 day evaluation period. Serum and urine creatinine concentrations were determined using both a modified Jaffe (autoanalyzer) method and an HPLC method. The data were analyzed using nonlinear mixed-effects modeling. RESULTS: Considering both statistical criteria and physiological conventions through allometric scaling theory, creatinin

@article{Nix.2006, abstract = {BACKGROUND: Estimation of renal function in patients with end-stage liver disease (ESLD) is complicated by several factors. OBJECTIVE: To develop a practical and relatively inexpensive method for estimating creatinine production and clearance in patients with ESLD. METHODS: Serum creatinine concentrations and urinary excretion of creatinine were measured in 27 patients with moderate-to-severe liver disease with the goal of developing equations to predict creatinine clearance from serum creatinine. Subjects were studied during an initial evaluation for a liver transplant program. Two 24 hour urine specimens were collected along with 3 serum samples over a 2 day evaluation period. Serum and urine creatinine concentrations were determined using both a modified Jaffe (autoanalyzer) method and an HPLC method. The data were analyzed using nonlinear mixed-effects modeling. RESULTS: Considering both statistical criteria and physiological conventions through allometric scaling theory, creatinin}, added-at = {2010-02-04T16:31:48.000+0100}, author = {Nix and Erstad, B. L. and Nakazato, P. Z. and Barletta, J. F. and Matthias, K. R. and Krueger, T. S.}, biburl = {https://www.bibsonomy.org/bibtex/2c93558f5f1bd9aa7d8cfb016695c3924/hruehs}, interhash = {63c92aab551039ebbfdf8c7cb27bec38}, intrahash = {c93558f5f1bd9aa7d8cfb016695c3924}, issn = {1060-0280}, journal = {ANNALS OF PHARMACOTHERAPY}, keywords = {CIRRHOSIS CREATININE GLOMERULAR-FILTRATION-RATE MARKERS PREDICTABILITY PREDICTION RENAL-FUNCTION SERUM SURVIVAL TRANSPLANTATION assay clearance creatinine disease function liver renal}, number = 5, pages = {900-908}, timestamp = {2010-02-04T16:31:52.000+0100}, title = {Estimation of creatinine clearance in end-stage liver disease}, volume = 40, year = 2006 }