%0 Journal Article %1 skattum_serum_2008 %A Skattum, L %A Gullstrand, B %A Holmström, E %A Oxelius, V-A %A Truedsson, L %D 2008 %J Clinical Immunology (Orlando, Fla.) %K Activity, Adolescent, Adult, Aged, Alleles, Allotypes, Bactericidal Blood C3 Child, Complement Factor, G, Genotype, Gm Humans, Immunoglobulin Middle Neisseria Nephritic Preschool, Proteins, System meningitidis %N 1 %P 123--131 %R 10.1016/j.clim.2008.06.010 %T Serum bactericidal activity against Neisseria meningitidis in patients with C3 nephritic factors is dependent on IgG allotypes %U http://www.ncbi.nlm.nih.gov/pubmed/18667363 %V 129 %X The main mechanisms of immune defense against Neisseria meningitidis are serum bactericidal activity (SBA) and opsonophagocytosis. Many complement deficiencies, among them acquired partial C3 deficiency due to stabilizing autoantibodies against the alternative pathway C3 convertase (C3 nephritic factors, C3 NeF); increase the risk of meningococcal infection. SBA against meningococci in patients with C3 NeF was determined along with allelic variants (GM alleles) of the immunoglobulin constant heavy G chain (IGHG) genes. In patients with C3 NeF and in control children, individuals homozygous for G1M*f and G3M*b showed higher SBA against meningococci than heterozygous individuals. Partial complement deficiency in early childhood might explain the influence of GM variants on SBA in control children. These novel findings imply that the IGHG genotype is important in defense against meningococci in individuals with low complement function and possibly in combination with other immunodeficiencies.

@article{skattum_serum_2008, abstract = {The main mechanisms of immune defense against Neisseria meningitidis are serum bactericidal activity {(SBA)} and opsonophagocytosis. Many complement deficiencies, among them acquired partial C3 deficiency due to stabilizing autoantibodies against the alternative pathway C3 convertase {(C3} nephritic factors, C3 {NeF);} increase the risk of meningococcal infection. {SBA} against meningococci in patients with C3 {NeF} was determined along with allelic variants {(GM} alleles) of the immunoglobulin constant heavy G chain {(IGHG)} genes. In patients with C3 {NeF} and in control children, individuals homozygous for {G1M*f} and {G3M*b} showed higher {SBA} against meningococci than heterozygous individuals. Partial complement deficiency in early childhood might explain the influence of {GM} variants on {SBA} in control children. These novel findings imply that the {IGHG} genotype is important in defense against meningococci in individuals with low complement function and possibly in combination with other immunodeficiencies.}, added-at = {2011-03-11T10:05:34.000+0100}, author = {Skattum, L and Gullstrand, B and Holmström, E and Oxelius, {V-A} and Truedsson, L}, biburl = {https://www.bibsonomy.org/bibtex/20b8a015b9b06cf4d27899d53f8bf63c0/jelias}, doi = {10.1016/j.clim.2008.06.010}, interhash = {6efc190ee7711646707db75e602169fd}, intrahash = {0b8a015b9b06cf4d27899d53f8bf63c0}, issn = {1521-7035}, journal = {Clinical Immunology {(Orlando,} Fla.)}, keywords = {Activity, Adolescent, Adult, Aged, Alleles, Allotypes, Bactericidal Blood C3 Child, Complement Factor, G, Genotype, Gm Humans, Immunoglobulin Middle Neisseria Nephritic Preschool, Proteins, System meningitidis}, month = oct, note = {{PMID:} 18667363}, number = 1, pages = {123--131}, timestamp = {2011-03-11T10:05:48.000+0100}, title = {Serum bactericidal activity against Neisseria meningitidis in patients with C3 nephritic factors is dependent on {IgG} allotypes}, url = {http://www.ncbi.nlm.nih.gov/pubmed/18667363}, volume = 129, year = 2008 }