Abstract
BACKGROUND: Germline mutations in recessive cancer predisposition
genes are uncovered by somatic genetic deletions during tumor development.
Analysis of genetic changes in tumor tissues from patients with an
inherited predisposition may therefore highlight regions of the genome
containing susceptibility or modifier genes. Our aim was to characterize
genetic changes in familial prostate cancer METHODS: Twenty-one primary
prostate cancers from 19 Finnish prostate cancer families were analyzed
for somatic genetic changes by comparative genomic hybridization
(CGH). RESULTS: The average number of genetic alterations per tumor
was 4.0 +/- 1.9, distributed equally among losses and gains. The
most common losses were found at chromosomal regions 13q14-q22 (29%),
8p12-pter (24%), and 6q13-q16 (14%), and the most common gains at
19p (25%), 19q (14%) and 7q (14%). CONCLUSIONS: These results suggest
that prostate cancers in genetically predisposed individuals arise
for the most part through similar somatic genetic progression pathways
as sporadic prostate cancers. This also implies that the biological
properties of tumors from the two groups may not be different from
one another.
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