%0 Journal Article %1 Werther.2002 %A Werther, K. %A Christensen, I. J. %A Nielsen, H. J. %D 2002 %J Br.J.Cancer %K 80 A Adult Aged Biological Carcinoma Colonic Colorectal Endothelial Factor Factors Female Growth Humans Lymphokines Male Markers Middle Neoplasm Neoplasms Plasma RANGE Rate Rectal Reference Research Staging Survival Time Tumor Values Vascular and blood mortality over pathology surgery %N 3 %P 417-423 %T Prognostic impact of matched preoperative plasma and serum VEGF in patients with primary colorectal carcinoma %U PM:11875709 %V 86 %X In serum, the major part of vascular endothelial growth factor derives from in vitro degranulation of granulocytes and platelets. Therefore, plasma may be preferred for vascular endothelial growth factor measurements. However, which specimen is the best predictor of survival is still debated. The present study analyzed the prognostic value of matched preoperative serum and plasma vascular endothelial growth factor concentrations in patients with colorectal cancer. To establish the reference range among healthy people, vascular endothelial growth factor was analyzed in 50 matched EDTA-plasma and serum samples from healthy blood donors. Preoperatively, in 524 patients with colorectal cancer, matched plasma and serum vascular endothelial growth factor concentrations were analyzed. In the colorectal cancer patients, the median plasma vascular endothelial growth factor concentration (44 pg ml(-1)) was significantly (P=0.01) higher than the median plasma vascular endothelial growth factor co

@article{Werther.2002, abstract = {In serum, the major part of vascular endothelial growth factor derives from in vitro degranulation of granulocytes and platelets. Therefore, plasma may be preferred for vascular endothelial growth factor measurements. However, which specimen is the best predictor of survival is still debated. The present study analyzed the prognostic value of matched preoperative serum and plasma vascular endothelial growth factor concentrations in patients with colorectal cancer. To establish the reference range among healthy people, vascular endothelial growth factor was analyzed in 50 matched EDTA-plasma and serum samples from healthy blood donors. Preoperatively, in 524 patients with colorectal cancer, matched plasma and serum vascular endothelial growth factor concentrations were analyzed. In the colorectal cancer patients, the median plasma vascular endothelial growth factor concentration (44 pg ml(-1)) was significantly (P=0.01) higher than the median plasma vascular endothelial growth factor co}, added-at = {2010-02-05T11:28:39.000+0100}, author = {Werther, K. and Christensen, I. J. and Nielsen, H. J.}, biburl = {https://www.bibsonomy.org/bibtex/2734684c829a9cc9dae40517d1fe53c8b/kanefendt}, interhash = {b7d8b79cdf68235edbfbd5ccb2517e9a}, intrahash = {734684c829a9cc9dae40517d1fe53c8b}, journal = {Br.J.Cancer}, keywords = {80 A Adult Aged Biological Carcinoma Colonic Colorectal Endothelial Factor Factors Female Growth Humans Lymphokines Male Markers Middle Neoplasm Neoplasms Plasma RANGE Rate Rectal Reference Research Staging Survival Time Tumor Values Vascular and blood mortality over pathology surgery}, number = 3, pages = {417-423}, timestamp = {2010-02-05T11:28:41.000+0100}, title = {Prognostic impact of matched preoperative plasma and serum VEGF in patients with primary colorectal carcinoma}, url = {PM:11875709}, volume = 86, year = 2002 }