Abstract
A simple, facile, efficient and three-component procedure for the
synthesis of
spiroindoline-3,4'-pyrazolo3,4-bpyridine-2,6'(1'H)-diones by the
reaction of 4-hydroxycumarin, isatins and 1H-pyrazol-5-amines in water
under ultrasonic irradiation is reported. The advantages of this method
are the use of an inexpensive and readily available catalyst, easy
work-up, good yields, and the use of water as a solvent that is
considered to be relatively environmentally benign. (C) 2009 Elsevier
B.V. All rights reserved.
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