Article,

Ultrasound-assisted one-pot, three-component synthesis of spiroindoline-3,4 `-pyrazolo3,4-bpyridine-2,6 `(1 ` H)-diones in water

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ULTRASONICS SONOCHEMISTRY, 17 (2): 447-452 (February 2010)
DOI: {10.1016/j.ultsonch.2009.09.009}

Abstract

A simple, facile, efficient and three-component procedure for the synthesis of spiroindoline-3,4'-pyrazolo3,4-bpyridine-2,6'(1'H)-diones by the reaction of 4-hydroxycumarin, isatins and 1H-pyrazol-5-amines in water under ultrasonic irradiation is reported. The advantages of this method are the use of an inexpensive and readily available catalyst, easy work-up, good yields, and the use of water as a solvent that is considered to be relatively environmentally benign. (C) 2009 Elsevier B.V. All rights reserved.

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