Abstract
Secnidazole is an old drug efficient as an antimicrobial agent used
against some anaerobic bacteria and parasites, such as giardia, ameba
and trichomonas that are causing some neglected diseases. This drug is
commercialized as a hemihydrate, being stable at room temperature, but
showing relevant phase transitions on heating. The understanding of the
dehydration process on solvates provides valuable information for
quality control and development of solid formulations. In order to study
the thermal behavior of secnidazole, Raman spectroscopy, X-ray powder
diffraction, hot-stage microscopy and thermal analysis were employed to
verify the structural modifications involved with this drug. Raman
spectroscopy was a key technique to monitor the dehydration process in
situ, providing the spectral fingerprints for identifying the anhydrous
form. In addition, the reported results suggest the existence of two
anhydrous monotropic polymorphs. (C) 2016 Elsevier B.V. All rights
reserved.
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