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GPCR and G proteins: drug efficacy and activation in live cells

, , , , , , , и . Mol Endocrinol, 23 (5): 590-9 (мая 2009)Vilardaga, Jean-Pierre Bunemann, Moritz Feinstein, Timothy N Lambert, Nevin Nikolaev, Viacheslav O Engelhardt, Stefan Lohse, Martin J Hoffmann, Carsten Research Support, Non-U.S. Gov't Review United States Molecular endocrinology (Baltimore, Md.) Mol Endocrinol. 2009 May;23(5):590-9. Epub 2009 Feb 5..

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Markus P J Mergens

Adrian P J Schulte

Armin J -P Bogs

Johannes P J Maassen

Wolfram J P Karges

 

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Kinetic analysis of G protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells, , , , и . Adv Protein Chem, (2007)Lohse, Martin J Hoffmann, Carsten Nikolaev, Viacheslav O Vilardaga, Jean-Pierre Bunemann, Moritz Research Support, Non-U.S. Gov't Review United States Advances in protein chemistry Adv Protein Chem. 2007;74:167-88..GPCR and G proteins: drug efficacy and activation in live cells, , , , , , , и . Mol Endocrinol, 23 (5): 590-9 (мая 2009)Vilardaga, Jean-Pierre Bunemann, Moritz Feinstein, Timothy N Lambert, Nevin Nikolaev, Viacheslav O Engelhardt, Stefan Lohse, Martin J Hoffmann, Carsten Research Support, Non-U.S. Gov't Review United States Molecular endocrinology (Baltimore, Md.) Mol Endocrinol. 2009 May;23(5):590-9. Epub 2009 Feb 5..A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells, , , , , , , , , и . Nat Methods, 2 (3): 171-6 (марта 2005)Hoffmann, Carsten Gaietta, Guido Bunemann, Moritz Adams, Stephen R Oberdorff-Maass, Silke Behr, Bjorn Vilardaga, Jean-Pierre Tsien, Roger Y Ellisman, Mark H Lohse, Martin J P41RR004050/RR/NCRR NIH HHS/United States Comparative Study Evaluation Studies Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. United States Nature methods Nat Methods. 2005 Mar;2(3):171-6. Epub 2005 Feb 17..Molecular mechanisms of receptor activation: real-time analysis by fluorescence resonance energy transfer, , и . Auton Autacoid Pharmacol, 23 (4): 231-3 (августа 2003)Lohse, Martin J Vilardaga, Jean-Pierre Bunemann, Moritz Lectures England Autonomic & autacoid pharmacology Auton Autacoid Pharmacol. 2003 Aug;23(4):231-3..Fluorescence resonance energy transfer analysis of alpha 2a-adrenergic receptor activation reveals distinct agonist-specific conformational changes, , , , , и . Mol Pharmacol, 75 (3): 534-41 (марта 2009)Zurn, A Zabel, U Vilardaga, J-P Schindelin, H Lohse, M J Hoffmann, C Comparative Study Research Support, Non-U.S. Gov't United States Molecular pharmacology Mol Pharmacol. 2009 Mar;75(3):534-41. Epub 2008 Dec 23..Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism, , , , и . Proc Natl Acad Sci U S A, 102 (44): 16084-9 (ноября 2005)Castro, Marian Nikolaev, Viacheslav O Palm, Dieter Lohse, Martin J Vilardaga, Jean-Pierre Research Support, Non-U.S. Gov't United States Proceedings of the National Academy of Sciences of the United States of America Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16084-9. Epub 2005 Oct 18..Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol, , , , , и . J Clin Invest, 117 (1): 229-35 (января 2007)Rochais, Francesca Vilardaga, Jean-Pierre Nikolaev, Viacheslav O Bunemann, Moritz Lohse, Martin J Engelhardt, Stefan Research Support, Non-U.S. Gov't United States The Journal of clinical investigation J Clin Invest. 2007 Jan;117(1):229-35..Measurement of the millisecond activation switch of G protein-coupled receptors in living cells, , , , и . Nat Biotechnol, 21 (7): 807-12 (июля 2003)Vilardaga, Jean-Pierre Bunemann, Moritz Krasel, Cornelius Castro, Marian Lohse, Martin J Comparative Study Research Support, Non-U.S. Gov't United States Nature biotechnology Nat Biotechnol. 2003 Jul;21(7):807-12. Epub 2003 Jun 15..Molecular basis of inverse agonism in a G protein-coupled receptor, , , и . Nat Chem Biol, 1 (1): 25-8 (июня 2005)Vilardaga, Jean-Pierre Steinmeyer, Ralf Harms, Greg S Lohse, Martin J Research Support, Non-U.S. Gov't United States Nature chemical biology Nat Chem Biol. 2005 Jun;1(1):25-8. Epub 2005 May 24..Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor association, , , , , и . J Biol Chem, 277 (10): 8121-9 (марта 2002)Vilardaga, Jean-Pierre Krasel, Cornelius Chauvin, Stephanie Bambino, Tom Lohse, Martin J Nissenson, Robert A DK 35323/DK/NIDDK NIH HHS/United States Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. United States The Journal of biological chemistry J Biol Chem. 2002 Mar 8;277(10):8121-9. Epub 2001 Nov 28..