The Selecton server enables detecting the selective forces at a single amino-acid site. The ratio of non-synonymous (amino-acid altering) to synonymous (silent) substitutions, known as the Ka/Ks ratio, is used to estimate both positive and purifying selection at each amino-acid site
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On February 12, 1809, the English naturalist Charles Darwin was born. He popularized the term 'natural selection' as a milestone in modern biology, which was introduced in his masterpiece 'On the Origin of Species' in 1859.