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MAP Kinase p38 Inhibitors: Clinical Results and an Intimate Look at Their Interactions with p38-alpha Protein

Mitogen-activated protein kinase p38 is a serin/threonine kinase originally isolated from lipopolysaccharide stimulated monocytes. There are 4 isoforms; p38-a activation has been most widely studied for inflammation... · http://www.ingentaconnect.com/content/ben/cmc/2005/00000012/00000025/art00007

5 years and 10 months ago

by avivagabriel

1

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International Immunopharmacology =.= Paeonol suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-α-stimulated human umbilical vein endothelial cells by blocking p38, ERK and nuclear factor-κB signaling pathways

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W7N-4MK0XXM-2&_user=4429&_coverDate=03%2F31%2F2007&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000059602&_version=1&_urlVersion=0&_userid=4429&md5=09397ae05a889367c48e91ab360a5805

5 years and 10 months ago

by avivagabriel

1

TNF-alpha activation activators adhesion apoptosis artery atherosclerosis botanical botanicals cardiology cardiovascular cellular chemokines chinese chronic coronary cytokines disease endothelial endothelium factor herbal herbals herbs immunology immunopharmacology inflammation inflammatory inhibition inhibitors interleukins kinase medicine mitogen-activating molecular molecules necrosis p38 p38-MAPK paeonol pathways peony protein signalling tumor

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Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-Activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine | Raingeaud et al | Journal of Biological Chemistry

http://www.jbc.org/cgi/content/abstract/270/13/7420?ijkey=04ae78ab267da06fcece55ebf1deeca2edc63795&keytype2=tf_ipsecsha

5 years and 10 months ago

by avivagabriel

1

(0)

ScienceDaily: Depressed Patients Experience Excessive Inflammation During Stressful Situations

http://www.sciencedaily.com/releases/2006/09/060901161240.htm

5 years and 10 months ago

by avivagabriel

1

chronic cytokines depression inflammation inflammatory stress

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Cytokines and cardiovascular disease =.= Mehra et al. =.= Journal of Leukocyte Biology

We describe how innate and adaptive immune cascades trigger the release of cytokines and chemokines, resulting in the initiation and progression of atherosclerosis. We discuss how cytokines have direct and indirect effects on myocardial function. · http://www.jleukbio.org/cgi/content/abstract/jlb.0405182v1

5 years and 10 months ago

by avivagabriel

1

(0)

Scientific Commons: The role of the pro-inflammatory cytokine Interleukin-18, its processing enzyme Caspase-1, and potential alternative IL-18-activating pathways in atherosclerosis (2005), 2005 [Gerdes, Norbert]

Atherosclerosis is the predominant underlying pathology of cardiovascular disease...atherosclerotic lesions are characterized by abundance of immune cells and their effector molecules, eventually leading to unstable angina, myocardial infarction, or strok · http://en.scientificcommons.org/7482600

5 years and 10 months ago

by avivagabriel

1

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