beta-Lactamases in laboratory and clinical resistance
D. Livermore. Clinical Microbiology Reviews, 8 (4):
557--584(October 1995)PMID: 8665470.
Abstract
beta-Lactamases are the commonest single cause of bacterial resistance to beta-lactam antibiotics. Numerous chromosomal and plasmid-mediated types are known and may be classified by their sequences or phenotypic properties. The ability of a beta-lactamase to cause resistance varies with its activity, quantity, and cellular location and, for gram-negative organisms, the permeability of the producer strain. beta-Lactamases sometimes cause obvious resistance to substrate drugs in routine tests; often, however, these enzymes reduce susceptibility without causing resistance at current, pharmacologically chosen breakpoints. This review considers the ability of the prevalent beta-lactamases to cause resistance to widely used beta-lactams, whether resistance is accurately reflected in routine tests, and the extent to which the antibiogram for an organism can be used to predict the type of beta-lactamase that it produces.
%0 Journal Article
%1 livermore_beta-lactamases_1995
%A Livermore, D M
%D 1995
%J Clinical Microbiology Reviews
%K Bacteria Bacteria, Enterobacteriaceae, Resistance, {Gram-Negative} {Gram-Positive} {beta-Lactamases,} {beta-Lactam}
%N 4
%P 557--584
%T beta-Lactamases in laboratory and clinical resistance
%U http://www.ncbi.nlm.nih.gov/pubmed/8665470
%V 8
%X beta-Lactamases are the commonest single cause of bacterial resistance to beta-lactam antibiotics. Numerous chromosomal and plasmid-mediated types are known and may be classified by their sequences or phenotypic properties. The ability of a beta-lactamase to cause resistance varies with its activity, quantity, and cellular location and, for gram-negative organisms, the permeability of the producer strain. beta-Lactamases sometimes cause obvious resistance to substrate drugs in routine tests; often, however, these enzymes reduce susceptibility without causing resistance at current, pharmacologically chosen breakpoints. This review considers the ability of the prevalent beta-lactamases to cause resistance to widely used beta-lactams, whether resistance is accurately reflected in routine tests, and the extent to which the antibiogram for an organism can be used to predict the type of beta-lactamase that it produces.
@article{livermore_beta-lactamases_1995,
abstract = {{beta-Lactamases} are the commonest single cause of bacterial resistance to beta-lactam antibiotics. Numerous chromosomal and plasmid-mediated types are known and may be classified by their sequences or phenotypic properties. The ability of a beta-lactamase to cause resistance varies with its activity, quantity, and cellular location and, for gram-negative organisms, the permeability of the producer strain. {beta-Lactamases} sometimes cause obvious resistance to substrate drugs in routine tests; often, however, these enzymes reduce susceptibility without causing resistance at current, pharmacologically chosen breakpoints. This review considers the ability of the prevalent beta-lactamases to cause resistance to widely used beta-lactams, whether resistance is accurately reflected in routine tests, and the extent to which the antibiogram for an organism can be used to predict the type of beta-lactamase that it produces.},
added-at = {2011-03-11T10:05:34.000+0100},
author = {Livermore, D M},
biburl = {https://www.bibsonomy.org/bibtex/23976dbe00692f867935433ae38326086/jelias},
interhash = {a48266856544ed7e7999eb69a9cd6e9f},
intrahash = {3976dbe00692f867935433ae38326086},
issn = {0893-8512},
journal = {Clinical Microbiology Reviews},
keywords = {Bacteria Bacteria, Enterobacteriaceae, Resistance, {Gram-Negative} {Gram-Positive} {beta-Lactamases,} {beta-Lactam}},
month = oct,
note = {{PMID:} 8665470},
number = 4,
pages = {557--584},
timestamp = {2011-03-11T10:05:54.000+0100},
title = {{beta-Lactamases} in laboratory and clinical resistance},
url = {http://www.ncbi.nlm.nih.gov/pubmed/8665470},
volume = 8,
year = 1995
}