%0 Journal Article %1 rodriguez-barradas_colonization_1997 %A Rodriguez-Barradas, M C %A Tharapel, R A %A Groover, J E %A Giron, K P %A Lacke, C E %A Houston, E D %A Hamill, R J %A Steinhoff, M C %A Musher, D M %D 1997 %J The Journal of Infectious Diseases %K Adult, Aged, Bacterial, Carrier Chain Count, Drug Factors, Humans, Infections, Lymphocyte Male, Microbial, Middle Pharyngitis, Pharynx, Polymerase Reaction, Resistance, Risk State, Streptococcal Streptococcus pneumoniae {CD4} {DNA,} {HIV} %N 3 %P 590--7 %T Colonization by Streptococcus pneumoniae among human immunodeficiency virus-infected adults: prevalence of antibiotic resistance, impact of immunization, and characterization by polymerase chain reaction with BOX primers of isolates from persistent S. pneumoniae carriers %U http://www.ncbi.nlm.nih.gov/pubmed/9041330 %V 175 %X Pharyngeal colonization by Streptococcus pneumoniae was evaluated in 103 human immunodeficiency virus (HIV)-infected subjects (\textless200 CD4 cells/microL, 57; \textgreater or = 200 CD4 cells/microL, 46) and 39 non-HIV-infected controls who were participants in a vaccine study. At baseline, 7\%, 20\%, and 10\% of subjects in the \textless200 and \textgreater or = 200 CD4 cell groups and in the control group were colonized with S. pneumoniae: Rates at 6 months were 23\%, 22\%, and 0\%, respectively. Of 34 isolates from HIV-infected subjects, 25 were penicillin-resistant and 19 were resistant to \textgreater or = 3 antimicrobials; of 8 isolates from controls, 1 was resistant. Resistance to trimethoprim-sulfamethoxazole was significantly higher among HIV-infected subjects with \textless200 CD4 cells/microL than in those with more CD4 cells. Polymerase chain reaction DNA analysis with BOX primers demonstrated that 12 HIV-infected subjects were persistently colonized with the same S. pneumoniae strain for \textgreater or = 1 month compared with none of the controls. HIV-infected subjects were more likely to be persistent pneumococcal carriers and to carry antibiotic-resistant isolates than were non-HIV-infected subjects.

@article{rodriguez-barradas_colonization_1997, abstract = {Pharyngeal colonization by Streptococcus pneumoniae was evaluated in 103 human immunodeficiency virus {(HIV)-infected} subjects ({\textless}200 {CD4} {cells/microL,} 57; {\textgreater} or = 200 {CD4} {cells/microL,} 46) and 39 {non-HIV-infected} controls who were participants in a vaccine study. At baseline, 7\%, 20\%, and 10\% of subjects in the {\textless}200 and {\textgreater} or = 200 {CD4} cell groups and in the control group were colonized with S. pneumoniae: Rates at 6 months were 23\%, 22\%, and 0\%, respectively. Of 34 isolates from {HIV-infected} subjects, 25 were penicillin-resistant and 19 were resistant to {\textgreater} or = 3 antimicrobials; of 8 isolates from controls, 1 was resistant. Resistance to trimethoprim-sulfamethoxazole was significantly higher among {HIV-infected} subjects with {\textless}200 {CD4} {cells/microL} than in those with more {CD4} cells. Polymerase chain reaction {DNA} analysis with {BOX} primers demonstrated that 12 {HIV-infected} subjects were persistently colonized with the same S. pneumoniae strain for {\textgreater} or = 1 month compared with none of the controls. {HIV-infected} subjects were more likely to be persistent pneumococcal carriers and to carry antibiotic-resistant isolates than were {non-HIV-infected} subjects.}, added-at = {2011-03-11T10:05:34.000+0100}, author = {{Rodriguez-Barradas}, M C and Tharapel, R A and Groover, J E and Giron, K P and Lacke, C E and Houston, E D and Hamill, R J and Steinhoff, M C and Musher, D M}, biburl = {https://www.bibsonomy.org/bibtex/2481d4747ba94fd78c771511f09274c54/jelias}, interhash = {3875b6908f82c978e43cd6e0eb9e8dda}, intrahash = {481d4747ba94fd78c771511f09274c54}, issn = {0022-1899}, journal = {The Journal of Infectious Diseases}, keywords = {Adult, Aged, Bacterial, Carrier Chain Count, Drug Factors, Humans, Infections, Lymphocyte Male, Microbial, Middle Pharyngitis, Pharynx, Polymerase Reaction, Resistance, Risk State, Streptococcal Streptococcus pneumoniae {CD4} {DNA,} {HIV}}, month = mar, note = {{PMID:} 9041330}, number = 3, pages = {590--7}, shorttitle = {Colonization by Streptococcus pneumoniae among human immunodeficiency virus-infected adults}, timestamp = {2011-03-11T10:06:47.000+0100}, title = {Colonization by Streptococcus pneumoniae among human immunodeficiency virus-infected adults: prevalence of antibiotic resistance, impact of immunization, and characterization by polymerase chain reaction with {BOX} primers of isolates from persistent S. pneumoniae carriers}, url = {http://www.ncbi.nlm.nih.gov/pubmed/9041330}, volume = 175, year = 1997 }