%0 Journal Article %1 Nguyen.1998 %A Nguyen, L. %A Chatelut, E. %A Chevreau, C. %A Tranchand, B. %A Lochon, I. %A Bachaud, J. M. %A Pujol, A. %A Houin, G. %A Bugat, R. %A Canal, P. %D 1998 %J Cancer chemotherapy and pharmacology %K & 80 Administration, Adult Aged Aged, Agents, Antineoplastic Availability Binding Biological Blood Chemistry, Clearance Etoposideadministration Female Humans Infusions, Intravenous Male Metabolic Middle Neoplasmsdrug Oral Pharmaceutical Phytogenicadministration Protein Proteinsmetabolism Rate Retrospective Studies and dosagebloodpharmacokinetics over therapymetabolism %N 2 %P 125-132 %T Population pharmacokinetics of total and unbound etoposide %V 41 %X A population pharmacokinetics study using the NONMEM program was undertaken to determine the effects of different covariates on the pharmacokinetic parameters of etoposide. A total of 1,044 plasma etoposide concentrations were determined by high-performance liquid chromatography (HPLC) in 100 patients (pts; 75 men and 25 women aged 25-85 years) treated for various tumor types with i.v. (57 pts) or oral (43 pts) etoposide. For 67 pts, etoposide plasma protein binding was determined by equilibrium dialysis; the unbound fraction ranged from 4% to 24%. A linear two-compartment model with first-order absorption (for oral dosing) accurately described the concentration versus time data. The central and peripheral volumes of distribution were significantly correlated with the body surface area Vc (L) = 5.5 x BSA (m2) and Vp = 4.1 x BSA, but even after BSA had been taken into account, the interindividual variability of the two volumes remained high (34% and 57%, respectively). The clearance (

@article{Nguyen.1998, abstract = {A population pharmacokinetics study using the NONMEM program was undertaken to determine the effects of different covariates on the pharmacokinetic parameters of etoposide. A total of 1,044 plasma etoposide concentrations were determined by high-performance liquid chromatography (HPLC) in 100 patients (pts; 75 men and 25 women aged 25-85 years) treated for various tumor types with i.v. (57 pts) or oral (43 pts) etoposide. For 67 pts, etoposide plasma protein binding was determined by equilibrium dialysis; the unbound fraction ranged from 4% to 24%. A linear two-compartment model with first-order absorption (for oral dosing) accurately described the concentration versus time data. The central and peripheral volumes of distribution were significantly correlated with the body surface area [Vc (L) = 5.5 x BSA (m2) and Vp = 4.1 x BSA], but even after BSA had been taken into account, the interindividual variability of the two volumes remained high (34% and 57%, respectively). The clearance (}, added-at = {2010-02-04T16:31:48.000+0100}, author = {Nguyen, L. and Chatelut, E. and Chevreau, C. and Tranchand, B. and Lochon, I. and Bachaud, J. M. and Pujol, A. and Houin, G. and Bugat, R. and Canal, P.}, biburl = {https://www.bibsonomy.org/bibtex/2af68725499130d6f7f3b21f9f2c2f2f5/hruehs}, interhash = {c978023db54d06a858ef01b439cc8aac}, intrahash = {af68725499130d6f7f3b21f9f2c2f2f5}, issn = {1432-0843}, journal = {Cancer chemotherapy and pharmacology}, keywords = {& 80 Administration, Adult Aged Aged, Agents, Antineoplastic Availability Binding Biological Blood Chemistry, Clearance Etoposideadministration Female Humans Infusions, Intravenous Male Metabolic Middle Neoplasmsdrug Oral Pharmaceutical Phytogenicadministration Protein Proteinsmetabolism Rate Retrospective Studies and dosagebloodpharmacokinetics over therapymetabolism}, number = 2, pages = {125-132}, timestamp = {2010-02-04T16:31:49.000+0100}, title = {Population pharmacokinetics of total and unbound etoposide}, volume = 41, year = 1998 }