%0 Journal Article %1 Debrah.2006 %A Debrah, A. Y. %A Mand, S. %A Specht, S. %A Marfo-Debrekyei, Y. %A Batsa, L. %A Pfarr, K. %A Larbi, J. %A Lawson, B. %A Taylor, M. %A Adjei, O. %A Hoerauf, A. %D 2006 %J PLoS.Pathog. %K & Adult Aged Animals C Data Doxycycline Elephantiasis Endothelial Factor Female Filarial Filaricides Growth Humans Hydrocele Intercellular Lymphatic Lymphedema Male Microfilaria Middle Molecular Outcome Parasitemia Peptides Plasma Proteins Receptor-3 Research Sequence Signaling System Testicular Testis Treatment Vascular Vessels Wolbachia and antagonists blood drug effects immunology inhibitors isolation parasitology pathology physiology protein purification therapeutic therapy ultrasonography use %N 9 %P e92 %T Doxycycline reduces plasma VEGF-C/sVEGFR-3 and improves pathology in lymphatic filariasis %U PM:17044733 %V 2 %X Lymphatic filariasis is a disease of considerable socioeconomic burden in the tropics. Presently used antifilarial drugs are able to strongly reduce transmission and will thus ultimately lower the burden of morbidity associated with the infection, however, a chemotherapeutic principle that directly induces a halt or improvement in the progression of the morbidity in already infected individuals would constitute a major lead. In search of such a more-effective drug to complement the existing ones, in an area endemic for bancroftian filariasis in Ghana, 33 microfilaremic and 18 lymphedema patients took part in a double-blind, placebo-controlled trial of a 6-wk regimen of 200 mg/day doxycycline. Four months after doxycycline treatment, all patients received 150-200 microg/kg ivermectin and 400 mg albendazole. Patients were monitored for Wolbachia and microfilaria loads, antigenemia, filarial dance sign (FDS), dilation of supratesticular lymphatic vessels, and plasma levels of lymphangioge

@article{Debrah.2006, abstract = {Lymphatic filariasis is a disease of considerable socioeconomic burden in the tropics. Presently used antifilarial drugs are able to strongly reduce transmission and will thus ultimately lower the burden of morbidity associated with the infection, however, a chemotherapeutic principle that directly induces a halt or improvement in the progression of the morbidity in already infected individuals would constitute a major lead. In search of such a more-effective drug to complement the existing ones, in an area endemic for bancroftian filariasis in Ghana, 33 microfilaremic and 18 lymphedema patients took part in a double-blind, placebo-controlled trial of a 6-wk regimen of 200 mg/day doxycycline. Four months after doxycycline treatment, all patients received 150-200 microg/kg ivermectin and 400 mg albendazole. Patients were monitored for Wolbachia and microfilaria loads, antigenemia, filarial dance sign (FDS), dilation of supratesticular lymphatic vessels, and plasma levels of lymphangioge}, added-at = {2010-02-05T11:28:39.000+0100}, author = {Debrah, A. Y. and Mand, S. and Specht, S. and Marfo-Debrekyei, Y. and Batsa, L. and Pfarr, K. and Larbi, J. and Lawson, B. and Taylor, M. and Adjei, O. and Hoerauf, A.}, biburl = {https://www.bibsonomy.org/bibtex/2ee1fa6cc385bc0da43b7dc0595066e27/kanefendt}, interhash = {d2babc31c548efc129751c99c4ac4831}, intrahash = {ee1fa6cc385bc0da43b7dc0595066e27}, journal = {PLoS.Pathog.}, keywords = {& Adult Aged Animals C Data Doxycycline Elephantiasis Endothelial Factor Female Filarial Filaricides Growth Humans Hydrocele Intercellular Lymphatic Lymphedema Male Microfilaria Middle Molecular Outcome Parasitemia Peptides Plasma Proteins Receptor-3 Research Sequence Signaling System Testicular Testis Treatment Vascular Vessels Wolbachia and antagonists blood drug effects immunology inhibitors isolation parasitology pathology physiology protein purification therapeutic therapy ultrasonography use}, number = 9, pages = {e92}, timestamp = {2010-02-05T11:28:54.000+0100}, title = {Doxycycline reduces plasma VEGF-C/sVEGFR-3 and improves pathology in lymphatic filariasis}, url = {PM:17044733}, volume = 2, year = 2006 }