%0 Journal Article %1 Mittendorf2003a %A Mittendorf, Robert %A Montag, Anthony G %A MacMillan, William %A Janeczek, Susan %A Pryde, Peter G %A Besinger, Richard E %A Gianopoulos, John G %A Roizen, Nancy %D 2003 %J Am J Obstet Gynecol %K Adult; Cerebral Palsy; Female; Fetal Blood; Diseases; Humans; Infant; Infant, Newborn; Inflammation; Interleukin-6; Male; Predictive Value of Tests; Pregnancy; Randomized Controlled Trials; Risk Factors; Sensitivity and Specificity; Umbilical Cord %N 6 %P 1438--4; discussion 1444-6 %T Components of the systemic fetal inflammatory response syndrome as predictors of impaired neurologic outcomes in children. %V 188 %X OBJECTIVE: The purpose of this study was to compare interleukin-6 and funisitis as predictors of impaired neurologic outcomes in children by performing a secondary analysis on data that were collected prospectively for another purpose. STUDY DESIGN: We examined umbilical cords for funisitis and obtained cord blood for interleukin-6 levels. A psychomotor developmental index score was determined for each child at age 18 months. RESULTS: The prevalence (46\%) of elevated interleukin-6 levels (> or = 10 pg/mL) among children with low psychomotor developmental index scores (<100) was not significantly different from that of children with normal scores (47\%). Among children with funisitis (n = 21), the median psychomotor developmental index score was 94; for children without funisitis (n = 92), it was 99 (P <.02). When the data were regressed for confounding, funisitis remained significant (adjusted odds ratio, 1.3; 95\% CI, 1.1-1.9). Furthermore, funisitis was a more specific predictor of low psychomotor developmental index scores (P <.001), although elevated interleukin-6 levels were more sensitive. CONCLUSION: When used for the prediction of impaired neurologic outcomes in children, funisitis has better specificity and thus a better positive predictive value than does interleukin-6.

@article{Mittendorf2003a, abstract = {OBJECTIVE: The purpose of this study was to compare interleukin-6 and funisitis as predictors of impaired neurologic outcomes in children by performing a secondary analysis on data that were collected prospectively for another purpose. STUDY DESIGN: We examined umbilical cords for funisitis and obtained cord blood for interleukin-6 levels. A psychomotor developmental index score was determined for each child at age 18 months. RESULTS: The prevalence (46\%) of elevated interleukin-6 levels (> or = 10 pg/mL) among children with low psychomotor developmental index scores (<100) was not significantly different from that of children with normal scores (47\%). Among children with funisitis (n = 21), the median psychomotor developmental index score was 94; for children without funisitis (n = 92), it was 99 (P <.02). When the data were regressed for confounding, funisitis remained significant (adjusted odds ratio, 1.3; 95\% CI, 1.1-1.9). Furthermore, funisitis was a more specific predictor of low psychomotor developmental index scores (P <.001), although elevated interleukin-6 levels were more sensitive. CONCLUSION: When used for the prediction of impaired neurologic outcomes in children, funisitis has better specificity and thus a better positive predictive value than does interleukin-6.}, added-at = {2014-07-19T20:48:18.000+0200}, author = {Mittendorf, Robert and Montag, Anthony G and MacMillan, William and Janeczek, Susan and Pryde, Peter G and Besinger, Richard E and Gianopoulos, John G and Roizen, Nancy}, biburl = {https://www.bibsonomy.org/bibtex/2aa2e8b5e12db00c6e6a506f1c35d1a6f/ar0berts}, groups = {public}, interhash = {e5831e87fb21d120d1b69cb7f989c906}, intrahash = {aa2e8b5e12db00c6e6a506f1c35d1a6f}, journal = {Am J Obstet Gynecol}, keywords = {Adult; Cerebral Palsy; Female; Fetal Blood; Diseases; Humans; Infant; Infant, Newborn; Inflammation; Interleukin-6; Male; Predictive Value of Tests; Pregnancy; Randomized Controlled Trials; Risk Factors; Sensitivity and Specificity; Umbilical Cord}, month = Jun, number = 6, pages = {1438--4; discussion 1444-6}, pii = {S000293780300334X}, pmid = {12824976}, timestamp = {2014-07-19T20:48:18.000+0200}, title = {Components of the systemic fetal inflammatory response syndrome as predictors of impaired neurologic outcomes in children.}, username = {ar0berts}, volume = 188, year = 2003 }